Anal cancer has been steadily increasing in the United States, with the biggest jumps among older women, especially White and Hispanic women, a new study presented at Digestive Disease Week 2025 (Abstract 76) found. According to the investigators, this shift challenges assumptions about high-risk groups and who should be screened.
“Rates of anal cancer are rising fastest among White and Hispanic women over 65—groups not traditionally considered high risk,” said coauthor Ashley Robinson, MD, a second-year internal medicine resident at Advocate Lutheran General Hospital. “While the exact reasons behind this trend remain unclear, most older women were beyond the recommended age for human papillomavirus (HPV) vaccination when it first became widely available.” HPV causes 90% of anal cancers.
Study Details
Researchers—led by Eli D. Ehrenpreis, MD, AGAF, FACG, Research Director, Internal Medicine residency at Advocate Lutheran General Hospital—analyzed data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database from 2017 to 2021. They found anal cancer increased by 2.9% for women and 1.6% for men. Anal cancers increased fastest among White women over 65 years, who saw a 4.3% increase during the 5-year study period, reaching 11.4 cases per 100,000 in 2021. If the trend continues, the incidence of anal cancer in women over age 65 would double in less than 17 years.
Hispanic women over age 65 had the second-highest rate of anal cancer, with 7.5 cases per 100,000 people in 2021 and a slower annual increase of 1.7%.
“It’s crucial that we promote HPV vaccination as a key tool for preventing anal cancer, while also keeping health-care providers informed as screening guidelines evolve,” Dr. Robinson said. “These findings highlight specific patient groups who may benefit from targeted screening for anal HPV and anal cancer.”
Still considered rare, anal cancer makes up approximately 1% of all gastrointestinal cancers, with more than 90% of cases linked to chronic HPV infection. While screening for anal HPV, dysplasia, and cancer is recommended for high-risk groups—identified as individuals with HIV, bone marrow transplant recipients, and other immunocompromised populations—older women addressed in this study are not included.
