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Prospective Study Explores Prostate Cancer and Treatment Outcomes By Race


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A study designed to enroll an equal number of Black and White men with advanced prostate cancer confirmed key findings that have been evident in retrospective analyses and suggest potential new avenues for treating Black patients who disproportionately die of the disease.

Researchers at Duke Cancer Institute enrolled 50 Black and 50 White men with advanced prostate cancer in order to observe whether there were outcome differences on treatment with the hormone therapy abiraterone acetate plus the steroid prednisone. In retrospective data reviews, the Duke researchers had previously found racial differences in prostate-specific antigen (PSA) responses among patients with advanced prostate cancer.

Daniel J. George, MD

Daniel J. George, MD

Published online by Daniel J. George, MD, and colleagues in the journal Cancer, the researchers confirmed trends indicating that Black men's PSA levels dropped further and more frequently than those of White men receiving the same therapy. These PSA changes, however, did not result in differences in disease progression or overall survival times.

Issues in Clinical Trials

But the survival finding has an important subtlety, said Dr. George, Professor in the Departments of Medicine and Surgery at Duke University School of Medicine. He noted that most drug studies among patients with prostate cancer include a small fraction of Black men that is far lower than their numbers in the larger population.

Exclusions typically result because Black men with prostate cancer are more likely to have other illnesses such as diabetes and high blood pressure, which study leaders often fear could put them at higher risk for complications. Additionally, there are deep historic and cultural reasons that Black men tend to decline participation in clinical studies.

For their study, however, the Duke team found that Black men were eager to join the clinical trial. They were able to enroll a much larger proportion of Black men than what most studies include, in part because the study was addressing a question pertaining to race. Additionally, they did not exclude men with comorbidities, asserting that since the treatment is approved by the U.S. Food and Drug Administration for this population, they should be inclusive of the patients they see in practice.

"When you look at the overall survival data for our study, they're equal between Black and White men," Dr. George said. "But given the prevalence of coexisting conditions in the Black men we enrolled, mortality should have actually been higher for them.

"Our finding that it was not higher is telling—it suggests Black men with prostate cancer can fare just as well as White [men], even with other health issues," he stated. "And it signals that future studies should consider enrolling Black men despite these often-disqualifying conditions."

Our finding that it was not higher is telling—it suggests Black men with prostate cancer can fare just as well as White [men], even with other health issues. And it signals that future studies should consider enrolling Black men despite these often-disqualifying conditions.
— Daniel J. George, MD

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Dr. George said the researchers also identified a possible marker of ancestry-dependent treatment outcomes that could help explain why Black men respond more readily to hormone therapy, potentially pointing to new ways to address advanced prostate cancer in Black men.

"We need to understand how genetic ancestry might affect treatment outcomes—especially disease responsiveness in prostate cancer—because we are now using and studying these therapies earlier in the disease where we have the opportunity to cure patients," said Dr. George.

"If there is a subgroup of patients with an ancestry-based predisposition for potential better response, we need to understand that. But to do so, we will need greater genetic diversity in our future study populations, especially among those with African ancestry. We aren't going to fully understand this genetic complexity by solely enrolling men with European ancestry."

Disclosure: For full disclosures of the study authors, visit acsjournals.onlinelibrary.wiley.com.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
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