Changes in RECIST Tumor Measures Correlate Linearly With Survival in Patients Treated With Checkpoint Inhibitors
The Response Evaluation Criteria in Solid Tumors (RECIST), used in many clinical trials to evaluate changes in tumor burden over time, classify objective tumor response into one of four categories—complete response, partial response, stable disease, or progressive disease—based on the percent of change in the sum of the longest diameters of a set of target lesions. An analysis of data from the SWOG S1609 trial conducted by the National Cancer Institute–funded National Clinical Trials Network (NCTN) found that in patients treated with immune checkpoint inhibitors, survival times correlate linearly with that change, rather than exhibiting threshold effects corresponding to those RECIST categories. This aligns with an earlier finding of a similar linear association with survival in patients treated with chemotherapy. These results were presented by Othus et al at the 2023 ASCO Annual Meeting (Abstract 2504).
“I think that using just partial and complete response rate to define the ‘success’ of a trial can miss a signal, because patients who haven’t achieved those levels of remission but also haven’t [had disease progression] do have an outcome that is associated with longer survival,” explained lead study author Megan Othus, PhD, a biostatistician at the SWOG Statistics and Data Management Center and the Fred Hutchinson Cancer Center.
Many early trials testing treatments in solid tumors rely on RECIST in measuring the effect the treatment has had on a patient’s cancer. At baseline, before a patient starts treatment, target lesions are identified—typically on computed tomography or magnetic resonance imaging scans—and their longest diameters are measured and totaled. This is the baseline value against which objective tumor response is evaluated.
In evaluating response from target lesions, the sum of these longest diameters must decrease by at least 30% for objective response to be categorized as a partial response; tumor shrinkage of less than 30% is labeled stable disease.
New Analysis Details
To evaluate the association between quantitative change in RECIST tumor burden and overall and progression-free survival, Dr. Othus’s team analyzed data from 720 patients with a variety of rare cancers who were treated with checkpoint inhibitor therapy in the S1609 DART (Dual Anti–CTLA-4 and Anti–PD-1 blockade in Rare Tumors) clinical trial. DART was a federally funded basket trial that evaluated the combination of ipilimumab plus nivolumab in treating 53 cohorts of patients with rare tumor subtypes.
For the analysis presented at the 2023 ASCO Annual Meeting, the researchers looked at the percent change in the sum of the longest diameters of target lesions between each patient’s baseline assessment and their first scan after starting treatment. They used log-rank tests and Cox regression models to evaluate the association of those changes with overall survival and progression-free survival times.
Dr. Othus said the results are already having an impact on correlative work being done as part of the S1609 DART trial.
“We are using this finding to inform our translational medicine analyses,” she said. “This increases the number of patients we are defining as having a ‘good’ outcome, which gives us more power to evaluate potential biomarkers associated with outcomes.”
Disclosure: Study S1609 was funded by the National Institutes of Health, the National Cancer Institute (NCI), and was supported in part by Bristol Myers Squibb Company through a Cooperative Research and Development Agreement between the company and the NCI. For full disclosures of the study authors, visit coi.asco.org.The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.