NSCLC Trial Shows Radiation May Overcome Primary Resistance to Pembrolizumab

1. Study examines radiation's effect on non–small cell lung cancer immunotherapy resistance.

2. Combination of radiation and pembrolizumab shows improved outcomes.

3. Focus on patients with 'cold' tumors and low mutation burden.

4. Multiomic analysis used 293 samples from 72 patients.

5. Patients exhibited expanded T-cell clones posttreatment.

6. Findings suggest radiation may enhance systemic immune responses.

7. Collaboration emphasized in translating research to clinical relevance.