Association of Type 2 Diabetes With Colorectal Cancer Risk and Survival by Tumor Immunity Status

Type 2 diabetes (T2D) is linked to an increased risk of colorectal cancer (CRC) and poorer survival outcomes in a German population-based study. The research, which included nearly 2,400 participants, categorized tumor immune status using a tumor immune cell score. Findings indicated that those with T2D and low immune infiltration had both higher odds of CRC (odds ratio, 1.39) and significantly reduced survival rates, prompting calls for targeted preventive strategies that combine metabolic and immune interventions for patients with T2D. Michael Hoffmeister, PhD, leads this investigation.