More research into the efficacy of a modified ketogenic diet may be beneficial for people with brain tumors, according to a new study published by Schreck et al in the journal Neurology. The diet, which is high in fat and low in carbohydrates, led to changes in the metabolism in the body and the brain among patients with astrocytomas.
The small study found that the diet was safe and feasible among patients in the study population—all of whom had completed radiation treatment and chemotherapy. The study was not designed to determine whether the diet could slow down tumor growth or improve survival.
“There are not a lot of effective treatments for these types of brain tumors, and survival rates are low, so any new advances are very welcome,” said study author Roy E. Strowd, MD, MS, MEd, of Wake Forest School of Medicine and a fellow of the American Academy of Neurology. “These cancer cells rely on glucose, or sugar, to divide and grow. Since the ketogenic diet is low in sugar, the body changes what it uses for energy—instead of carbohydrates, it uses what are called ketones. Normal brain cells can survive on ketones, but the theory is that cancer cells cannot use ketones for energy.”
Dietary Intervention Details
The study involved 25 people with astrocytomas. They followed a type of ketogenic diet—the modified Atkins diet with intermittent fasting—for 8 weeks. The diet includes foods such as bacon, eggs, heavy cream, butter, leafy green vegetables, and fish. Participants met with a dietician at the start of the study and then every 2 weeks. Five days a week, they followed the modified Atkins diet, which combined carbohydrate restriction with high amounts of fats. Two days a week, they fasted, eating up to 20% of their recommended daily calorie amount.
Results
The main goal of the study was to see if people were able to follow the diet with no serious side effects. A total of 21 people completed the study, and 48% followed the diet completely, according to their food records. Urine tests showed that 80% of the people reached the level where their body was primarily using fats and protein for fuel, rather than carbohydrates.
The diet was well tolerated. Two people had serious side effects during the study; one was not related to the diet, and one was possibly related.
By the end of the study, changes in the metabolism in the body and the brain were seen. Hemoglobin A1c levels, insulin levels, and fat body mass all decreased, and lean body mass increased. Specialized brain scans that detect changes in brain metabolites showed an increase in concentrations of ketones and metabolic changes in the tumor.
“Of course, more studies are needed to determine whether this diet can prevent the growth of brain tumors and help people live longer, but these results show that the diet can be safe for people with brain tumors and successfully produce changes in the metabolism of the body and the brain,” said Dr. Strowd.
A limitation of the study is that study team members provided a high amount of contact with participants, which may not be feasible in a larger study or in routine clinical care.
Disclosure: The study was supported by Dr. John and Elaine Freeman; Dr. Jon Weingart; the Martz, Redwood, and Dalos families; the National Center for Advancing Translational Sciences, National Institutes of Health; and National Cancer Institute. For full disclosures of the study authors, visit n.neurology.org.
