Advertisement

Effect of Physical Activity on Disease-Free Survival in Patients Receiving Adjuvant Therapy for Stage III Colon Cancer


Advertisement
Get Permission

As reported in the Journal of Clinical Oncology by Brown et al, a prospective cohort study nested within the phase III CALGB/SWOG 80702/Alliance trial showed that greater volumes of physical activity in patients receiving adjuvant therapy for stage III colon cancer were associated with significant improvements in disease-free survival.

Study Details

In the trial, 2,524 patients were randomly assigned between June 2010 and November 2015 to adjuvant therapy with 3 vs 6 months of fluorouracil, leucovorin, and oxaliplatin with or without celecoxib. A total of 1,696 patients were enrolled in the nested cohort of diet and lifestyle study. Recreational physical activity was measured in the first 3 months of chemotherapy and at 6 months after completion of chemotherapy.  

Among patients with stage III colon cancer enrolled in a trial of postoperative treatment, larger volumes of recreational physical activity, longer durations of light- to moderate-intensity aerobic physical activity, or any vigorous-intensity aerobic physical activity were associated with the greatest improvements in disease-free survival.
— Brown et al

Tweet this quote

Key Findings

During a median follow-up of 5.9 years, 457 of the 1,696 patients experienced disease recurrence or death.

For total recreational physical activity volume, 3-year disease-free survival was 76.5% with fewer than 3.0 metabolic equivalent task hours per week (MET-h/wk; n = 486) vs 87.1% with at least 18.0 MET-h/wk (n = 483; risk difference = 10.6%, 95% confidence interval [CI] = 4.7%–19.4%, P < .001).  

For light-intensity to moderate-intensity activities, 3-year disease-free survival was 65.7% with 0.0 h/wk (n = 80) vs 87.1% with at least 1.5 h/wk (n = 722; risk difference = 21.4%, 95% CI = 9.2%–37.1%, P < .001).

For vigorous-intensity activity, 3-year disease-free survival was 76.0% with 0.0 h/wk (n = 657) vs 86.0% with at least 1.0 h/wk (n = 516; risk difference = 10.0%, 95% CI = 4.5%–18.9%, P < .001).

For brisk walking, 3-year disease-free survival was 81.7% with fewer than 1.0 h/wk (n = 902) vs 88.4% with at least 3.0 h/wk (n = 335; risk difference = 6.7%, 95% CI = 3.0%–13.8%, P < .001).

For muscle-strengthening activity, 3-year disease-free survival was 81.8% with 0.0 h/wk (n = 1,270) vs 88.8% for at least 0.5 h/wk (n = 209; risk difference = 7.0%, 95% CI = 3.1%–14.2%, P = .003).

The investigators concluded: “Among patients with stage III colon cancer enrolled in a trial of postoperative treatment, larger volumes of recreational physical activity, longer durations of light- to moderate-intensity aerobic physical activity, or any vigorous-intensity aerobic physical activity were associated with the greatest improvements in disease-free survival.”

Justin C. Brown, PhD, of the Pennington Biomedical Research Center, Department of Cancer Energetics, is the corresponding author of the Journal of Clinical Oncology article.

Disclosure: The study was supported by grants from the National Cancer Institute and others. For full disclosures of the study authors, visit ascopubs.org.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
Advertisement

Advertisement



Advertisement