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Can Consumption of Vitamin D Reduce the Risk of Early-Onset Colorectal Cancer?


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Consuming higher amounts of vitamin D—mainly from dietary sources—may help protect against developing young-onset colorectal cancer or precancerous colon polyps, according to the first study to show such an association. These findings were published by Kim et al in the journal Gastroenterology.

The study could potentially lead to recommendations for higher vitamin D intake as an inexpensive complement to screening tests as a colorectal cancer prevention strategy for adults younger than age 50.

While the overall incidence of colorectal cancer has been declining, cases have been increasing in younger adults. The authors of the study noted that vitamin D intake from food sources such as fish, mushrooms, eggs, and milk has decreased in the past several decades. There is growing evidence of an association between vitamin D and risk of colorectal cancer mortality. However, prior to the current study, no research has examined whether total vitamin D intake is associated with the risk of young-onset colorectal cancer.

“Vitamin D has known activity against colorectal cancer in laboratory studies. Because vitamin D deficiency has been steadily increasing over the past few years, we wondered whether this could be contributing to the rising rates of colorectal cancer in young individuals,” said study senior coauthor Kimmie Ng, MD, MPH, Director of the Young-Onset Colorectal Cancer Center at Dana-Farber. “We found that total vitamin D intake of 300 IU per day or more—roughly equivalent to three 8-oz glasses of milk—was associated with an approximately 50% lower risk of developing young-onset colorectal cancer.”


We found that total vitamin D intake of 300 IU per day or more—roughly equivalent to three 8-ounce glasses of milk—was associated with an approximately 50% lower risk of developing young-onset colorectal cancer.
— Kimmie Ng, MD, MPH

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Study Methodology

The results of the study were obtained by calculating the total vitamin D intake—both from dietary sources and supplements—of 94,205 women participating in the Nurses’ Health Study II (NHS II). This study is a prospective cohort study of nurses aged 25 to 42 years that began in 1989. Every 2 years, the participants receive questionnaires on demographics, diet and lifestyle factors, and medical and other health-related information. The researchers focused on a primary endpoint: young-onset colorectal cancer, diagnosed before 50 years of age. They also asked on a follow-up questionnaire whether participants had had a colonoscopy or sigmoidoscopy where colorectal polyps (which may be precursors to colorectal cancer) were found.

Association Between Vitamin D Intake and Risk of Colorectal Cancer

During the period from 1991 to 2015, the researchers documented 111 cases of young-onset colorectal cancer and 3,317 colorectal polyps. Analysis showed that higher total vitamin D intake was associated with a significantly reduced risk of early-onset colorectal cancer (hazard ratio [HR] for ≥ 450 IU/d vs < 300 IU/d = 0.49, 95% confidence interval [CI] = 0.26–0.93, P for trend = .01). The hazard ratio per 400 IU/d increase was 0.46 (95% CI = 0.26–0.83).

The same link was found between higher vitamin D intake and risk of colon polyps detected before age 50.

For colorectal cancer precursors, the odds ratios per 400 IU/d increase were 0.76 (95% CI = 0.65–0.88) for conventional adenoma (n = 1,439) and 0.85 (95% CI = 0.75–0.97) for serrated polyp (n = 1,878).

The association was stronger for dietary vitamin D—principally from dairy products—than from vitamin D supplements. The study authors said that finding could be due to chance or to unknown factors that are not yet understood.

The researchers didn’t find a significant association between total vitamin D intake and risk of colorectal cancer diagnosed after age 50; the findings were not able to explain this inconsistency, and the scientists said further research in a larger sample is necessary to determine if the protective effect of vitamin D is actually stronger in young-onset colorectal cancer.

In any case, the investigators concluded that higher total vitamin D intake is associated with decreased risks of young-onset colorectal cancer and precursors (polyps).

“Our results further support that vitamin D may be important in younger adults for health and possibly colorectal cancer prevention,” said Dr. Ng. “It is critical to understand the risk factors that are associated with young-onset colorectal cancer so that we can make informed recommendations about diet and lifestyle, as well as identify high-risk individuals to target for earlier screening.”

Disclosure: The study was funded by grants from the National Institutes of Health and the Department of Defense, the American Cancer Society Mentored Research Scholar Grant, and the Project P Fund. For full disclosures of the study authors, visit gastrojournal.org.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
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