In a Korean study reported in the American Journal of Surgical Pathology, Lee et al identified clinicopathologic and immunohistochemical characteristics of neuroendocrine carcinomas of the gallbladder.
The study involved data from 34 patients with gallbladder neuroendocrine carcinomas who had undergone surgery between January 2008 and December 2016 at Asan Medical Center, Seoul. Overall, 68% of patients were women, and median age at diagnosis was 63 (range = 37–82 years).
Histologic features included the following:
Immunohistochemical characteristics included the following:
Complete resection was achieved in 91% of patients. Twenty-five patients (68%) received adjuvant chemoradiation. Among all patients, 1-, 3-, and 5-year overall survival rates were 64%, 35%, and 19%, respectively. On univariate analysis, increasing American Joint Committee on Cancer stage (hazard ratio [HR] = 1.79, P = .032) and receipt of adjuvant chemoradiation (HR = 0.25, P = .002) were significantly associated with survival; on multivariate analysis, only receipt of adjuvant therapy remained significant (HR = 0.295, P = .007). For patients who received vs had not received chemoradiation, 1-year overall survival rates were 68% vs 22% and median overall survival was 19 months vs 10 months.
The authors stated, “The complete resection and application of postoperative adjuvant therapy may influence a better clinical outcome in patients with neuroendocrine carcinomas of the gallbladder.”
Sun Mi Lee, MD, of the Department of Pathology, Jeju National University Hospital, Jeju-si, is the corresponding author for the American Journal of Surgical Pathology article.
Disclosure: The study was supported by a grant from Jeju National University Hospital. For full disclosures of the study authors, visit journals.lww.com.The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.