Conversion of Unresectable Into Resectable Pancreatic Cancer: Chemoradiotherapy vs Chemotherapy

1. Trial name: CONKO-007; 2. Study inclusion: 495 patients with unresectable pancreatic tumors; 3. Treatment: Induction chemotherapy followed by CRT or continued chemotherapy; 4. R0 resection rates: 25% (CRT) vs 18% (chemotherapy); 5. Surgery improved overall survival (HR = 0.525); 6. No overall survival difference between CRT and chemotherapy; 7. R0 resection rates higher in surgically treated patients receiving CRT; 8. Study supported by German Cancer Aid.