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Local Recurrence With Radiation Boost in HER2-Positive Breast Cancer: HERA Trial Analysis


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In a retrospective analysis reported in the International Journal of Radiation Oncology • Biology • Physics, Joseph Abi Jaoude, MD, of the American University of Beirut Medical Center, and colleagues found that a radiation boost did not reduce the risk of local recurrence among women with HER2-positive breast cancer receiving breast-conserving surgery, whole-breast irradiation, and adjuvant trastuzumab in the phase III HERA trial.1 The HERA trial, which now has a median follow-up of 11 years, established the benefit of adjuvant trastuzumab in patients with HER2-positive breast cancer.

Study Details

The analysis included data from 1,082 women in the HERA trial (n = 5,099) who received breast-conserving surgery, whole-breast irradiation, and adjuvant trastuzumab. Among this population, 441 patients received an additional radiation boost to the primary tumor bed and 641 received no boost.

Patients randomly assigned to the observation arm (those who did not receive trastuzumab), those who did not receive radiotherapy, and those who underwent mastectomy were excluded from the analysis. The primary outcome measure for the analysis was local recurrence.

Key Findings

At median follow-up of 11 years, local recurrence was observed in 7.21% of all patients included in the analysis. Rates were 6.35% in the boost group vs 7.80% in the no-boost group (absolute reduction = 1.4%; P = .33). On multivariate analysis, the adjusted hazard ratio [HR] for boost vs no boost was 0.8 (P = .30).

Patients younger than age 40 had a higher risk for local recurrence than did older women. Among women younger than age 40, local recurrence occurred in 8.89% of the boost group vs 11.11% of the no-boost group (adjusted HR = 1.0, P = .92). The rate among patients aged 40 or older was 5.70% vs 6.99% (adjusted HR = 0.7, P = .29).

KEY POINTS

  • Local recurrence was observed in 7.21% of all patients included in the analysis; the rate was 6.35% in the boost group vs 7.80% in the no-boost group.
  • Patients younger than age 40 had a higher risk for local recurrence than did older women.
  • No significant differences in local recurrence rates were identified according to hormone receptor status.

No significant differences in local recurrence rates were identified according to hormone receptor status. Among patients with estrogen receptor–negative and progesterone receptor–negative disease, the rate was 8.95% in the boost group vs 8.05% in the no-boost group (adjusted HR = 1.0, P = .98). Among patients with estrogen receptor–positive or progesterone receptor–positive disease, the rates were 4.38% with a boost and 7.55% without a boost (adjusted HR = 0.6, P = .11).

The investigators concluded: “[Patients with] HER2-positive breast cancer treated with breast-conserving surgery, whole-breast radiation, and trastuzumab have excellent local control. Delivery of an additional radiation boost in this patient population was not shown to improve local control. Future studies are needed to identify subgroups of HER2-positive patients who derive a clinically relevant benefit from radiation boost.” 

Disclosure: For full disclosures of the study authors, visit redjournal.org.

REFERENCE

1. Jaoude JA, Kayali M, Azambuja EA, et al: De-intensifying radiation therapy in HER-2 positive breast cancer: To boost or not to boost? Int J Radiat Oncol Biol Phys. August 27, 2020 (early release online).


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