Myles Brown, MD
Celina Kleer, MD
The San Antonio Breast Cancer Symposium (SABCS) and the American Association for Cancer Research (AACR) will honor two renowned researchers for their work in breast cancer at the 2019 SABCS, to be held December 10–14 in San Antonio. Myles Brown, MD, is the recipient of the 2019 AACR Distinguished Lectureship in Breast Cancer Research award. Celina Kleer, MD, will receive the 2019 AACR Outstanding Investigator Award for Breast Cancer Research.
Dr. Brown, the Emil Frei III Professor of Medicine at Dana-Farber Cancer Institute and Harvard Medical School, is being recognized for his pioneering research involving steroid receptor co-regulators, which has put a spotlight on the dynamic ability of these proteins to regulate the genome. Notably, his research has elucidated the epigenetic factors underlying the action of steroid hormones and effectively shaped the current understanding of the role of nuclear hormone receptors in normal physiology and breast cancer. Dr. Brown will deliver a lecture on December 12 titled “Essential Genes and Cistromes in Breast Cancer.”
Dr. Kleer, the Harold A. Oberman Collegiate Professor of Pathology at the University of Michigan Medical School and Rogel Cancer Center, is being recognized for her work in generating key insights into the development of aggressive forms of breast cancer and for advancing the characterization of clinical biomarkers and potential therapeutic targets for these cancer subsets. Specifically, her groundbreaking research led to both the initial demonstration of EZH2 overexpression in metastatic hormone receptor–negative breast cancer and the elucidation of molecular determinants of metaplastic breast carcinoma. Dr. Kleer will present a lecture on December 13 titled “Novel Non-canonical Functions of EZH2 in Triple-Negative Breast Cancer.” ■
