NCCN Clinical Practice Guidelines in Oncology: 2025 Updates

1. NCCN released updates to its Clinical Practice Guidelines in Oncology at the 30th Annual Conference. 2. The Guidelines showcased significant changes in the management of bladder cancer and differentiated thyroid cancer. 3. The systemic therapy recommendations for multiple malignancies were influenced by recent clinical trial findings. 4. Perioperative chemotherapy with FLOT became the new 'preferred' primary treatment for resectable locally advanced esophageal and esophagogastric junction adenocarcinomas. 5. Integrating immunotherapy was a key update to the NCCN Guidelines for Small Cell Lung Cancer.