This Clinical Trials Resource Guide lists actively recruiting clinical trials evaluating strategies to improve cancer prevention measures, mostly through increased rates of screening. Some of the following trials also address cancer prevention through improving knowledge of tumor biomarkers, patient health literacy, and other factors that may affect screening. This selection of trials focuses on the following tumor sites: breast, cervical, colorectal, gastric, and ovarian.
More information on these trials and other similar trials is available on the National Institutes of Health’s website at ClinicalTrials.gov.
Study Title: Participatory Research to Advance Colon Cancer Prevention
Study Type: Interventional/crossover assignment
Study Sponsor and Collaborators: Kaiser Permanente/Oregon Health and Science University/AltaMed Health Services
Purpose: To test strategies to increase the rate of colorectal cancer screening among the Latino population
Primary Outcome Measures: Increased colorectal cancer screening rates [time frame: up to 4 years]
Principal Investigator: Gloria Coronado, PhD, Kaiser Permanente; contact Jamie Thompson, MPH, at (503) 335-6335 or jamie.h.thompson@kpchr.org
ClinicalTrials.gov Identifier: NCT03167125
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Study Title: Community-Based Cervical Cancer Prevention and Education Among Women Living With HIV
Study Type: Interventional/parallel assignment
Study Sponsor and Collaborators: Johns Hopkins University
Purpose: To test whether health literacy–focused interventions delivered by trained community health workers will be effective in promoting health literacy and increasing Pap test rates in women living with HIV
Primary Outcome Measures: Completion of Pap test [time frame: 6 months]
Principal Investigator: Hae-Ra Han, PhD, John Hopkins University School of Nursing; contact Dr. Han at (410) 614-2669 or hhan3@jhu.edu
ClinicalTrials.gov Identifier: NCT03033888
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Study Title: A Pilot Study of Hydroxytyrosol, a Component of Olive Oil, for Breast Cancer Prevention in Women at High Risk of Breast Cancer
Study Type: Interventional/single-group assignment
Study Sponsor and Collaborators: The Methodist Hospital System
Purpose: To evaluate the effect of hydroxytyrosol on mammographic density in women at high risk of developing breast cancer
Primary Outcome Measures: Breast density as assessed by mammography [time frame: 3 years]
Principal Investigator: Tejal Patel, MD, The Methodist Hospital System; contact the Houston Methodist Cancer Center at (713) 441-0629 or ccresearch@houstonmethodist.org
ClinicalTrials.gov Identifier: NCT02068092
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Study Title: Patient-Centered Cancer Prevention in Chinese Americans
Study Type: Interventional/parallel assignment
Study Sponsor and Collaborators: NYU Langone Health/National Institute on Minority Health and Health Disparities
Purpose: To assess the efficacy, adoption, and impact of an integrated intervention to improve adherence to recommended stomach cancer prevention guidelines for at-risk Chinese Americans in New York City
Primary Outcome Measures: Change in Helicobacter pylori eradication measured using breath ammonia measurement, fecal stool antigen test, or another clinically approved H pylori infection diagnostic test [time frame: at 2 months and at 6 months]
Principal Investigator: Simona Kwon, DrPH, MPH; contact Janet Pan at (212) 263-0483 or Janet.Pan@nyulangone.org
ClinicalTrials.gov Identifier: NCT03340454
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Study Title: Northwestern Ovarian Cancer Early Detection and Prevention Program: A Specimen and Data Study
Study Type: Observational/prospective
Study Sponsor and Collaborators: Northwestern University/National Cancer Institute
Purpose: To identify and develop highly sensitive and specific tumor markers for the detection and management of ovarian cancer and other gynecologic malignancies by collecting specimens and data
Primary Outcome Measures: Identification and development of highly sensitive and specific tumor markers for the detection and management of ovarian cancer and other gynecologic malignancies [time frame: outcomes will be assessed at the completion of the study]
Principal Investigator: Lee P. Shulman, MD, Robert H. Lurie Cancer Center; contact the Clinical Trials Office at the Robert H. Lurie Comprehensive Cancer at (312) 695-1301 or cancer@northwestern.edu
ClinicalTrials.gov Identifier: NCT00005095
Editor’s Note: The clinical trials presented here do not represent all the trials listed on ClinicalTrials.gov. For the complete list, go to ClinicalTrials.gov.
