Immunotherapy with immune checkpoint inhibitors is the first of a new generation of immunotherapy treatments, revolutionizing treatment for many different types of cancer. By unleashing the body’s immune system to attack cancer, these treatments can send even the most hard-to-treat cancers into lasting remission.
Patients who receive immune checkpoint inhibitors, however, may experience a unique set of side effects. These side effects can involve multiple organs of the body, and although they are typically mild, sometimes severe, irreversible, or even life-threatening reactions can occur. Given that these therapies have entered the clinic fairly recently, few clinicians are experienced in recognizing and treating associated side effects.
New guidelines developed collaboratively by ASCO and the National Comprehensive Cancer Network (NCCN) offer clinicians much-needed recommendations for assessment and management of side effects related to immune checkpoint inhibitors.
“With rapidly increasing use of immune checkpoint inhibitors, it is imperative that clinicians are knowledgeable about their unique toxicity profiles,” said ASCO Chief Executive Officer Clifford A. Hudis, MD, FACP, FASCO. “These new guidelines from ASCO and NCCN will help our community continue to provide the highest quality of care to all patients as they incorporate these agents into routine care.”
There are already several checkpoint inhibitors approved by the U.S. Food and Drug Administration (FDA) for various cancers, including melanoma; Hodgkin lymphoma; and lung, liver, kidney, and bladder cancers. The use of checkpoint inhibitors is continuously expanding to more indications, along with the development of new checkpoint inhibitors and combinations.
“The real winners here are patients whose health-care teams now have high-quality, collaborative guidelines from ASCO and NCCN to minimize treatment toxicity and optimize outcomes,” said NCCN Chief Executive Officer Robert W. Carlson, MD. “While novel immunotherapies allow for life-extending therapy for selected forms of cancer, their success is associated with potentially substantial toxicity. These side effects are different from other forms of anticancer therapy and require rapid and appropriate recognition and treatment. NCCN has been pleased to collaborate with ASCO on developing strategies and collaborative guidelines for managing the toxicity of immunotherapies.”
Immunotherapy-related side effects can occur at any time and can affect any organ. The most common side effects are rash, diarrhea, low thyroid hormone, and fatigue, but they can also include inflammation of the lung, intestines, or liver; hormonal abnormalities; and kidney, heart, or neurologic problems.
“If you take the brakes off the immune system and allow it to attack cancer, it may also attack the healthy tissue in a patient’s body,” said John A. Thompson, MD, Chair of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Panel on Management of Immunotherapy-Related Toxicity and Co-Chair of the expert panel that developed the ASCO guideline. “Fortunately, most of the side effects are reversible, but early recognition and proper treatment are critical.”
Key Guideline Recommendations
- In general, checkpoint inhibitors can be continued with close monitoring for mild (grade 1) toxicities, with the exception of neurologic and some hematologic toxicities.
- For moderate (grade 2) toxicities, checkpoint inhibitors should be held until symptoms and/or lab values revert to grade 1 levels or lower. Corticosteroids may be offered.
- For severe (grade 3) toxicity, patients should receive high-dose corticosteroids for at least 6 weeks. Extreme caution when restarting immunotherapy after a grade 3 toxicity is recommended, if it is restarted at all.
- In general, very severe (grade 4) toxicity necessitates stopping checkpoint inhibitor therapy permanently.
- Consult the guidelines directly for more specific recommendations depending on which organ is affected.
To develop the guidelines, ASCO and NCCN convened multidisciplinary panels with representation from medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, and nursing, as well as patient advocacy experts. The clinical recommendations are based on a systematic review of the literature and an informal consensus process. These guidelines pertain only to immune checkpoint inhibitors, not to other types of immunotherapy. NCCN will update its guidelines continuously as data evolve and plans to include toxicities of new chimeric antigen receptor (CAR) T-cell therapies later this year.
“Some people will brush their symptoms aside, but any unusual symptom should be reported to the doctor,” said Julie Brahmer, MD, Co-Chair of the expert panel that developed the ASCO guideline. “These guidelines will help all providers who care for patients treated with immune checkpoint inhibitors—not just oncologists, but also emergency room and primary care doctors—assess and manage these side effects.”
“The Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Clinical Practice Guideline” and “NCCN Guidelines® for Management of Immunotherapy-Related Toxicities” were published in February 2018 in the Journal of Clinical Oncology and online at NCCN.org, respectively.
Patients can find information about side effects of immunotherapy at Cancer.Net, or download an infographic at NCCN.org/infographic. An educational video is available at https://youtu.be/BTrlDgaNyjQ.
ASCO and NCCN encourage feedback on their guidelines from oncologists, practitioners, and patients through the ASCO Guidelines Wiki at www.asco.org/guidelineswiki or via the NCCN submission form at NCCN.org. ■
Originally published in ASCO Connection. © American Society of Clinical Oncology. “ASCO, NCCN Provide Guidance on Understanding and Managing Immunotherapy Side Effects.” ASCOconnection.org, February 14, 2018. All rights reserved.
