How a Commonly Inherited Genetic Alteration Is Driving Breast Cancer Metastasis and Predicting Survival

1. A germline variant in the PCSK9 gene drives breast cancer metastasis. 2. Inherited genetics, rather than somatic mutations, may play a critical role in metastasis. 3. Therapeutics targeting the PCSK9 gene variant could alter future treatments for metastatic breast cancer. 4. The study suggests a hereditary contribution to cancer metastasis in breast cancer and melanoma. 5. The PCSK9 gene may be a potential target for prophylactic treatment.