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Capivasertib for AKT1 E17K–Mutated Metastatic Cancers: NCI-MATCH Subprotocol EAY131-Y


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Kevin Kalinsky, MD, MS

Kevin Kalinsky, MD, MS

As reported in JAMA Oncology by Kevin Kalinsky, MD, MS, and colleagues, the NCI-MATCH trial’s phase II subprotocol EAY131-Y has shown activity of the pan-AKT inhibitor capivasertib in a range of metastatic tumors with an AKT1 E17K mutation.

The phase II trial enrolled 35 evaluable adult patients with an AKT1 E17K–mutated metastatic tumor between July 2016 and August 2017 whose disease had progressed on standard treatment. Patients received oral capivasertib at 480 mg twice daily for 4 days on and 3 days off weekly in 28-day cycles until disease progression or unacceptable toxicity. Among patients with metastatic breast cancer receiving hormone therapy, the dose was 400 mg twice daily. The primary endpoint was objective response rate.

The most common cancers included in the trial were breast cancer (n = 18, 51%)—including 15 patients with hormone receptor (HR)-positive/HER2-negative disease and 3 with triple-negative disease—and gynecologic cancers (n = 11, 31%).

Key Findings

An objective response was achieved in 10 patients (28.6%, 95% confidence interval = 15%–46%, P < .001 vs the null rate of 5%). A confirmed complete response was observed in one patient with endometrioid endometrial adenocarcinoma, who remained on therapy for 35.6 months at last follow-up. Among the nine patients with a confirmed partial response, seven had HR-positive/HER2-negative breast cancer, one had uterine leiomyosarcoma, and one had oncocytic carcinoma of the parotid gland. The median duration of response was 4.4 months (range = 3.1 to ≥ 31.7 months).

Four patients were categorized as having stable disease on the basis of missing follow-up scans confirming partial response. An additional 16 patients (46%) had stable disease.

At median follow-up of 28.4 months, median progression-free survival was 5.5 months (range = 0–35 months), with a 6-month rate of 50%. Median overall survival was 14.5 months.

The most common grade 1 or 2 adverse events were diarrhea, fatigue, nausea, proteinuria, hyperglycemia, and anorexia. Capivasertib was discontinued due to adverse events in 11 patients (31%), including discontinuation due to hyperglycemia in 3.

The investigators concluded, “This nonrandomized trial found that, in patients with an AKT1 E17K–mutated tumor treated with capivasertib, a clinically significant objective response rate was achieved, including one complete response. Clinically meaningful activity with single-agent capivasertib was demonstrated in refractory malignant neoplasms, including rare cancers.”

Kalinsky K et al: JAMA Onc. December 30, 2020 (early release online).


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