On November 17, 2016, the American Society for Radiation Oncology (ASTRO) issued an updated clinical practice statement for accelerated partial-breast irradiation for early-stage breast cancer. The updated guideline reflects recent evidence that greater numbers of patients may benefit from accelerated treatment and also provides direction for the use of intraoperative radiation therapy for partial-breast irradiation. The update to the 2009 ASTRO consensus statement for accelerated partial-breast irradiation was published by Correa et al in Practical Radiation Oncology.1
Carefully selected patients may achieve similar tumor control following shorter, targeted schedules of radiation as they would with weeks of radiation to the whole breast.— Jay R. Harris, MD, FASTRO
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The guideline was based on a systematic literature review of studies published since May 2008, the last date searched for the original clinical practice statement. A total of 419 abstracts were retrieved from PubMed, and the 44 articles that met inclusion criteria were abstracted into evidence tables and evaluated by an 8-member task force of radiation oncologists, medical oncologists, and experts in intraoperative radiotherapy. The clinical practice statement was approved by ASTRO’s Board of Directors following a 4-week period of public comment.
Patients with early-stage breast cancer often receive radiation therapy following breast-conserving surgery to lower the chance of recurrence or metastasis, generally in the form of whole-breast irradiation using external-beam radiation delivered over several weeks. Accelerated partial-breast irradiation is a newer, localized alternative that delivers the effective radiation dose directly to the tissue at risk. This targeted therapy reduces treatment time and may limit adverse side effects, particularly those involving the heart and lungs. More than 75,000 women in the United States have received accelerated partial-breast irradiation since its introduction in the late 1990s.
General Factors to Consider
Drawing on evidence published in the past 8 years, the guideline suggests that more patients with breast cancer can benefit from accelerated partial-breast irradiation, including younger patients and those with low-risk ductal carcinoma in situ. The guideline recommends considering the following factors for the use of accelerated partial-breast irradiation outside of clinical trial settings:
Recommendations for Intraoperative Radiotherapy
The update also provides guidance for the use of intraoperative radiotherapy for patients with early-stage breast cancer, drawing on two large, phase III clinical trials that compared whole-breast irradiation with intraoperative radiotherapy. Partial-breast irradiation may be administered by a variety of methods, including brachytherapy, external-beam irradiation, and intraoperative radiotherapy. Recommendations for the use of intraoperative radiotherapy follow:
“As trials mature and evidence accumulates, we can understand more comprehensively who benefits from accelerated radiation treatment following lumpectomy, and we are finding that the pool of suitable candidates for this emerging treatment is larger than first anticipated,” said Jay R. Harris, MD, FASTRO, Chair of the Task Force that developed the guideline and Distinguished Professor of Radiation Oncology at the Dana-Farber Cancer Institute, Harvard Medical School. “Carefully selected patients may achieve similar tumor control following shorter, targeted schedules of radiation as they would with weeks of radiation to the whole breast.” ■
Disclosure: For full disclosures of the statement authors, visit practicalradonc.org.
1. Correa C, Harris EE, Leonardi MC, et al: Accelerated partial breast irradiation: Executive summary for the update of an ASTRO evidence-based consensus statement. Pract Radiat Oncol. September 17, 2016 (early release online).