Final Overall Survival Confirms Benefit of Durvalumab Plus FLOT in Resectable Gastric and Gastroesophageal Junction Adenocarcinomas
By JULIA CIPRIANO, MS, CMPP
December 10, 2025: Supplement – Conference Highlights ESMO 2025
1. Durvalumab improves survival in gastric cancer patients. 2. MATTERHORN trial involved 948 patients with resectable tumors. 3. Significant overall survival benefits across PD-L1 expression levels. 4. Higher event-free survival observed with durvalumab plus FLOT. 5. Pathologic complete response rates higher with the combination therapy. 6. Study results support changing treatment standards.