Upfront Radical Cytoreductive Surgery Extends Progression-Free Survival in Advanced Ovarian Cancer

The TRUST trial is a significant phase III study that evaluated the effectiveness of primary cytoreductive surgery versus interval surgery in patients with advanced ovarian cancer. Led by Dr. Sven Mahner, the trial demonstrated improved progression-free survival without compromising the quality of life, although it failed to reach its primary endpoint of overall survival. The findings underscore the importance of high complete resection rates, particularly in patients with stage IIIC disease, advocating for the reevaluation of surgical approaches in this patient population.