SABCS 2018: SOLAR-1: Liquid Biopsies in Predicting Benefit of Alpelisib in PIK3CA-Mutant Breast Cancer
Liquid biopsy–based assessment of PIK3CA mutational status served as a better indicator of progression-free survival compared with analysis of tissue biopsy in patients with breast cancer enrolled in the phase III SOLAR-1 clinical trial, according to data presented by Juric et al at the 2018 San Antonio Breast Cancer Symposium (Abstract GS3-08).
“While the primary endpoint of the SOLAR-1 trial was determined based on PIK3CA mutations in any available tumor tissue, such as archival or fresh tissue, liquid biopsy analysis can be performed on a plasma sample obtained just prior to the initiation of treatment,” said Dejan Juric, MD, Director of the Termeer Center for Targeted Therapies at the Massachusetts General Hospital Cancer Center. “Our analysis reveals that [patients with] advanced breast cancer with detectable PIK3CA mutations in their blood have a more impressive benefit when alpelisib [an investigational selective PI3K-alpha inhibitor] is added to fulvestrant [Faslodex] for their treatment compared to patients with PIK3CA mutations detected in their tissue.”
Study Methods
Utilizing information from the SOLAR-1 trial, Dr. Juric and colleagues analyzed data from 341 patients with hormone receptor–positive, HER2-negative advanced breast cancer with PIK3CA mutations, as determined by tissue biopsy, who had received prior endocrine therapy. Patients were randomly assigned to receive either fulvestrant and alpelisib or fulvestrant and placebo. The median follow-up time was 20 months.
In addition to tissue-based analysis, the researchers evaluated progression-free survival by PIK3CA mutational status as measured in circulating tumor DNA. Progression-free survival was also analyzed by line of metastatic treatment, and by prior exposure to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors.
Results and Limitations
While patients with PIK3CA mutations as evaluated in tissue samples had a 35% reduction in risk for disease progression, the risk reduction was 45% for patients with PIK3CA mutations as evaluated in circulating tumor DNA.
“Compared to tissue DNA, circulating tumor DNA is a very easily accessible source of material for mutation profiling,” said Dr. Juric. “The finding that assessing mutational status via liquid biopsy resulted in even larger clinical benefit compared to tissue biopsy, with improvement of median [progression-free survival] from 3.7 months to 10.9 months, further highlights the clinical utility of this biospecimen.”
Compared with patients in the placebo arm, those who received alpelisib as the second line of treatment in the metastatic setting had a 39% reduction in risk for disease progression; the risk reduction was 33% for those who did not receive prior treatment with CDK4/6 inhibitors. There was also a 52% (nonsignificant) reduction in risk for participants who received prior treatment with CDK4/6 inhibitors.
Patients enrolled in the alpelisib arm experienced increased incidences of hyperglycemia, diarrhea, nausea, and rash compared to the placebo arm (65% vs 9%; 54% vs 11%; 46% vs 20%; and 40% vs 6%, respectively).
“PI3K-alpha is important for insulin signaling, and PI3K-alpha inhibition results in insulin resistance; hyperglycemia is therefore an on-target effect inextricably linked with the activity of alpelisib,” explained Dr. Juric. “Early detection and serial monitoring of elevated glucose, initiation of appropriate dietary measures, as well as early initiation of metformin and other insulin sensitizers are essential for adequate management of these patients.”
Limitations of this study include a small number of patients who received prior treatment with CDK4/6 inhibitors. “Larger studies specifically focused on post-CDK4/6 patients are needed to further characterize the role of alpelisib in this setting,” Dr. Juric noted.
Disclosure: The study was sponsored by Novartis. The study authors’ full disclosures may be found at sabcs.org.
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