SNMMI 2017: Immuno-PET Shows Promise for Detecting and Treating Pancreatic Tumors, Other Solid Tumors
A first-in-human study presented at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) (Abstract 385) demonstrated the feasibility and safety of imaging with the novel human monoclonal antibody HuMab-5B1, to enable highly specific targeting for the cancer antigen (CA) 19-9, which is expressed on pancreatic tumors and a variety of other malignancies including small cell lung cancer and tumors of the gastrointestinal system. It holds the promise of better identifying tumors and directing treatment.
“This new agent is intensely accumulated in pancreatic cancer and finds very small metastases with PET/CT imaging,” explained Christian Lohrmann, MD, lead author of the study from Memorial Sloan Kettering Cancer Center. “There are promising data that HuMab-5B1 could become a theranostic drug used in both targeted imaging and therapy, which could eventually improve the prognosis for pancreatic cancer patients.”
HuMab-5B1
The researchers evaluated the antibody with and without radiolabeling with zirconium-89 (89Zr-DFO-HuMab-5B1). With further validation, 89Zr-DFO-HuMab-5B1 could lead to a host of improvements in pancreatic cancer management—more accurate staging of tumors, better surgical guidance, restaging of metastases, and potential drug selection for CA 19-9 targeted therapies. The high uptake of the antibody alone suggests that it could be used by itself, radiolabeled, or coupled with another molecular compound to treat high-risk pancreatic tumors that are inoperable or metastatic.
For this study, nine patients with CA 19-9-positive metastatic malignancies underwent a series of four whole-body positron-emission tomography (PET)/computed tomography (CT) scans—one the first day of injection with the imaging agent, then again on day 2 and around days 4 and 7. Subjects also received a diagnostic CT scan of the chest, abdomen, and pelvis within the 4 weeks leading up to baseline PET/CT. Results of the CT scan were used to verify the results of 89Zr-DFO-HuMab-5B PET/CT imaging.
Major Findings
Maximum standard uptake values normalized for body weight were analyzed for agent uptake in tumors. The agent was well-tolerated and led to no serious side effects. Significant uptake was detected in local tumor recurrences as well as in metastases (in the lymph nodes, lungs, bone, and peritoneum lining of the abdominal cavity). Uptake was analyzed for a total of 52 lesions. Highest uptake was shown on day 7 in the lymph nodes. Results of the study showed that PET/CT imaging with the monoclonal antibody led to the detection of tiny tumors in the peritoneum and mesenteric lymph nodes that were not found by CT alone.
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