An international panel of experts has released updated evidence-based and expert opinion–based recommendations for the diagnosis and treatment of acute myeloid leukemia (AML) in adults. The recommendations were issued by the European LeukemiaNet (ELN) and published by Döhner et al in Blood.
“These guidelines are an important update of the current widely used recommendations for managing AML, for constructing clinical trials, and for predicting outcomes of AML patients,” said Clara D. Bloomfield, MD, Distinguished University Professor, Ohio State University Cancer Scholar and Senior Adviser, and the William Greenville Pace III Endowed Chair in Cancer Research at The Ohio State University Medical Center. “They will be the new standard of care and will replace the 2010 ELN recommendations for managing AML patients and designing clinical trials.”
Changes in Recommendations
The updated recommendations include revised ELN genetic categories, a proposed response category based on minimal residual disease status, and a proposed category for progressive disease for clinical trials. They also include the newly updated World Health Organization classification of myeloid neoplasms and acute leukemia.
Dr. Bloomfield, who co-chaired the expert panel, said updating the ELN recommendations was prompted by new insights into the molecular and genomic causes of the disease, by the development of new genetic tests and tests for detecting minimal residual disease, and by the development of novel antileukemic agents.
The panel that produced the new guidelines included 22 international members with recognized expertise in AML clinical practice and research. Dr. Bloomfield noted three particularly significant changes in the updated ELN recommendations:
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