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Poorer Outcome in Favorable-Histology Wilms Tumor Associated With Chromosome 1q Gain Reported in U.S. Study

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Key Points

  • Chromosome 1q gain was associated with poorer event-free survival among all patients with favorable-histology Wilms tumor and across disease stages.
  • Chromosome 1q gain was associated with poorer overall survival among all patients and in stages I and IV disease.

The Children’s Oncology Group found that chromosome 1q gain is associated with poorer event-free and overall survival in patients with favorable-histology Wilms tumor. Gratias et al reported these findings in the Journal of Clinical Oncology.

Study Details

The study involved analysis of unilateral favorable-histology Wilms tumors from 1,114 patients in National Wilms Tumor Study-5 with previously determined information on 1p and 16q microsatellite marker status and that proved informative for 1q gain, 1p loss, and 16q loss using multiplex ligation–dependent probe amplification.

Event-Free and Overall Survival

In the entire cohort, 8-year event-free survival was 86%, including 77% among 317 patients (28%) with tumors with 1q gain vs 90% among those lacking 1q gain (P < .001); 8-year overall survival was 88% vs 96% (P < .001). The presence of 1q gain was associated with poorer event-free survival in stage I (85% vs 95%, P = .0052), stage II (81% vs 87%, P = .0775), stage III (79% vs 89%, P = .01), and stage IV disease (64% vs 91%, P = .001) and with significantly poorer overall survival in stage I (90% vs 98%, P = .0015) and stage IV disease (74% vs 92%, P = .011).

On multivariate analysis, 1q gain was associated with an increased relative risk of relapse of 2.4 (P < .001); 1p loss was associated with an increased risk on univariate but not multivariate analysis.

The investigators concluded: “Gain of 1q is associated with inferior survival in unilateral [favorable-histology Wilms tumors] and may be used to guide risk stratification in future studies.”

The study was supported by grants from the National Institutes of Health.

Elizabeth J. Perlman, MD, of Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University, is the corresponding author of the Journal of Clinical Oncology article.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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