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Showing 7951 - 8000Targeted Methylation Sequencing Assay May Provide New Tool for Cancer Detection Across Stages and Tissues of Origin
A study by Geoffrey R. Oxnard, MD, and colleagues using bisulfite sequencing of plasma cell-free DNA to identify methylomic signatures for multicancer detection and tissue-of-origin determination found the assay achieved accurate detection of multiple cancers across stages and tissue-of-origin...
ASTRO Honors 2019 Gold Medalists, Honorary Member, and Other Award Recipients
The American Society for Radiation Oncology (ASTRO) recognized the recipients of its 2019 Gold Medal awards and other high-profile honors at the 2019ASTRO Annual Meeting. Gold Medalists and Honorary Member Walter J. Curran, Jr, MD;Silvia C. Formenti, MD, FASTRO; and Thomas R. Mackie, PhD, were...
Immunotherapy Combinations Redefine Outcomes for Patients With Advanced Renal Cell Carcinoma
The treatment landscape for patients with advanced renal cell carcinoma has changed drastically over the past several years with the introduction of many new therapeutic options for patients. The revolution began with the U.S. Food and Drug Administration (FDA) approval of nivolumab and ipilimumab...
LEAD Conference Awards 2019 Woman Oncologist of the Year
Claire Verschraegen, MD, was named the 2019 Woman Oncologist of the Year, and Shikha Jain, MD, FACP, received the 2019 Rising Star award at the first-ever Leadership Empowerment and Development: Enriching Experiences for Women in Hematology and Oncology (LEAD) Conference, hosted by Bio Ascend. An ...
Machine-Learning Model May Predict Unplanned Hospitalizations After Radiation Therapy for Gastrointestinal Cancer
Unplanned hospitalizations may be common among patients with cancer, but they diminish quality of care while racking up high costs for patients and the health-care system alike. According to data presented at the 2019 ASCO Quality Care Symposium, however, a new predictive model may help providers...
Nearly One-Quarter of Completed Lung Cancer Clinical Trials Remain Unpublished
A new analysis has found that the results of up to one-fourth of completed lung cancer clinical trials are not published. This finding was published in a research letter by Al-Shbool et al in JAMA Network Open. “It is surprising to see that a quarter of trials that have been completed end up not...
Studies Report Efficacy of Proton Radiotherapy for Hepatocellular Carcinoma
Two new studies published in the International Journal of Radiation Oncology • Biology • Physics focused on the use of proton radiation therapy to treat patients with hepatocellular carcinoma. The first study, by Sanford et al, found that proton radiation may extend overall survival compared to...
Ravi Thadhani, MD, MPH, Named Chief Academic Officer at Partners HealthCare
Ravi Thadhani, MD, MPH, was named Chief Academic Officer at Partners HealthCare, starting November 11, 2019. Dr. Thadhani most recently served as Vice Dean of Research and Graduate Research Education at Cedars-Sinai Medical Center in Los Angeles. Prior to that, he served as Associate Director of...
ACCC Honors Seven Cancer Programs With Innovator Awards
ACCC Honors Seven Cancer Programs With Innovator Awards The Association of Community Cancer Centers (ACCC) honored the recipients of 2019 ACCC Innovator Awards at the ACCC 36th National Oncology Conference, October 30–November 1 in Orlando, Florida, where this year’s honorees shared innovative...
Scientific Session on Breast Cancer Explores Studies on Partial-Breast Irradiation, Chemoradiotherapy
Women with early-stage breast cancer treated with lumpectomy followed by radiation therapy rated the cosmetic results for whole-breast and partial-breast irradiation to be equivalent, according to a new analysis of results from the phase III NRG Oncology/NSABP B39-RTOG 0413 clinical trial. Results...
FDA Office of Hematology Oncology Products Reorganizes, Renamed Office of Oncologic Diseases
As part of modernization plans approved in September 2019, the U.S. Food and Drug Administration (FDA) office responsible for reviewing applications for new and existing cancer therapies has reorganized and been renamed. The Center for Drug Evaluation and Research (CDER) Office of Hematology and...
American College of Physicians Issues Guidance on Colorectal Cancer Screening for Average-Risk, Asymptomatic Adults Aged 50 to 75 Years
The American College of Physicians has issued a new guidance statement on colorectal cancer screening, which recommends screening for average-risk adults who do not have symptoms and are between the ages of 50 and 75 years. The guidelines were published by Qaseem et al in Annals of Internal...
Study Finds Nearly One in Four Oncologists Rarely or Never Mention Cost When Discussing Genomic Testing
Nearly one in four oncologists report rarely or never discussing the costs of genomic testing with their patients, according to a new study led by American Cancer Society investigators. The study, published by Yabroff et al in the Journal of the National Cancer Institute, found that oncologists...
FDA Approves Pegfilgrastim Biosimilar
On November 5, the U.S. Food and Drug Administration (FDA) approved a biosimilar to pegfilgrastim, pegfilgrastim-bmez (Ziextenzo). Pegfilgrastim-bmez is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with nonmyeloid malignancies receiving...
2019 Annual Meeting of the American Thyroid Association Briefs
The American Thyroid Association held its 2019 Annual Meeting from October 30 to November 3 in Chicago. Below are brief summaries of important oral presentations on thyroid cancer from the meeting. Incidence and Incidence-Based Mortality in a State Results of a retrospective analysis of thyroid...
Stephen Hahn, MD, to Be Nominated FDA Commissioner
In a press release issued by the White House today, President Donald J. Trump announced his intention to nominate Stephen Hahn, MD, FASTRO, to be the Commissioner of Food and Drugs at the Department of Health and Human Services. Dr. Hahn has been Chief Medical Executive at The University of Texas...
AACR-NCI-EORTC: Investigational KRAS G12C Inhibitor for KRAS-Mutant Solid Tumors
The investigational KRAS G12C inhibitor MRTX849 yielded clinical responses in patients with non–small cell lung cancer (NSCLC) and colorectal cancer harboring KRAS G12C mutations, according to data from a phase I clinical trial presented at the AACR-NCI-EORTC International Conference on Molecular...
AACR-NCI-EORTC: Selumetinib for Adult Patients With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas
The investigational MEK inhibitor selumetinib showed clinical activity in adult patients with neurofibromatosis type 1 (NF1)-associated plexiform neurofibromas, according to preliminary results from an ongoing phase II study presented at the AACR-NCI-EORTC International Conference on Molecular...
First Survivor Views Survey Highlights Barriers to Addressing Side Effects of Cancer Treatment
Barriers to accessing appropriate therapies to address the physical and psychological side effects of cancer treatment continue to persist for patients and survivors, according to results of the Survivor Views survey conducted by the American Cancer Society Cancer Action Network (ACS CAN)....
Contrast-Enhanced Ultrasound May Help to Predict Cirrhotic Nodule Transformation to Hepatocellular Carcinoma
An article published by Lin et al in the American Journal of Roentgenology has identified sonographic biomarkers that may predict eventual malignant transformation of pathologically confirmed cirrhotic nodules for patients at risk for hepatocellular carcinoma. Lead investigator Manxia Lin, MD, of...
Palliative Care Bill Unanimously Approved by U.S. House of Representatives
On October 28, the U.S. House of Representatives unanimously approved the Palliative Care and Hospice Education and Training Act (PCHETA). The bipartisan bill would increase federal research funding for palliative care—including pain and symptom management—and would establish palliative care...
ASCO National Cancer Opinion Survey: Cancer Prevention, E-Cigarette, and End-of-Life Knowledge Gaps Reported
One in four Americans say they incorporate cancer prevention into their daily lives, according to ASCO’s third annual National Cancer Opinion Survey, despite research showing that as many as half of all cancer cases are preventable. The survey found low levels of awareness of known cancer risk...
Global Burden of Pancreatic Cancer From 1990–2017
The incidence and mortality rates of pancreatic cancer have increased in 195 countries and territories over a 27-year period, according to a systematic analysis performed within the Global Burden of Disease Study 2017 and published in The Lancet Gastroenterology & Hepatology. The study is the...
Conquerors Circle Recognizes Donors
The Conquerors Circle is Conquer Cancer, the ASCO Foundation’s appreciation society for donors who contribute $1,000 annually. In recognition of their generous and loyal support, Conquerors Circle members receive special recognition, which includes exclusive offerings for the ASCO Annual Meeting....
Behind the Breakthroughs: The Family Plan
Developed by Conquer Cancer, the Your Stories podcast series shares unscripted conversations among patients, doctors, and the family and friends who conquer cancer with them. The series also includes transcripts of conversations. Oncologist Sonali M. Smith, MD, and her husband, Norm Smith, MD,...
Why Do You Live to Conquer Cancer?
Oncologists are a special breed of physician who enter a patient’s life during one of the most distressing and often traumatic life experiences: a cancer diagnosis. That’s just the start of the journey, which can last many years and involve great successes and disappointments. This unique...
Leave a Legacy of Hope
By including a planned gift to Conquer Cancer ®, the ASCO Foundation, in your estate plans, you can help make a dramatic difference for patients with cancer years into the future. With just one small change to your will or trust, your planned gift of any size will deliver a big impact, and: Your...
Top Research From 2019 Quality Care Symposium Focuses on Cost of Cancer Care, Patient Participation in Clinical Trials
The 2019 Quality Care Symposium took place September 6–7, 2019, in San Diego. Abstracts presented at the symposium focused on efforts to improve the quality of care for patients with cancer. Highlights from this year’s meeting included research on the cost of care and patient participation in...
ASCO’s Journal of Global Oncology Informs Cancer Care Everywhere
As part of ASCO’s commitment to improving cancer care delivery and outcomes around the world, it publishes the Journal of Global Oncology (JGO). JGO Editorial Board member Lawrence N. Shulman, MD, has been a proponent of global thinking and global action in cancer care throughout his career. Dr....
Support Your Patients With ASCO Answers Fact Sheets
Direct, easy to understand, and in a convenient single-page format, ASCO Answers fact sheets introduce patients and their caregivers to types of cancer and cancer-related topics, including diagnosis, treatment, and side effects. Each fact sheet includes a topic overview, illustration, methods for...
Vipul Patel, MD, and Craig Reynolds, MD, Join AON Board
The American Oncology Network, LLC (AON), whose mission is to support the long-term viability of community oncology, has named Vipul Patel, MD, and Craig Reynolds, MD, to its Board. The AON Board provides strategic guidance to its growing network of physicians and physician practices, currently in...
Long-Term Survival Outcomes With New Treatments for Advanced Melanoma: Questions Still in Need of Answers
The major treatment advances for melanoma can be attributed to anti–-cytotoxic T-lymphocyte–associated protein 4 (anti–CTLA-4; ipilimumab) and anti–programmed cell death protein 1 (anti–PD-1; nivolumab, pembrolizumab) immune checkpoint inhibitors and the combination of BRAF and MEK inhibitors...
Susan G. Komen Names Three Recipients of the 2019 Brinker Awards for Scientific Distinction
Susan G. Komen recently named Jane Visvader, PhD; George Lindeman, MBBS, PhD; and Matthew J. Ellis, BSc, MB, BChir, PhD, FRCP, as this year’s recipients of the Brinker Awards for Scientific Distinction. The 2019 Brinker Award winners will deliver keynote lectures at the upcoming 2019 San Antonio ...
Dana-Farber Cancer Institute Receives $5 Million Gift to Create the Center for Myelodysplastic Syndromes
A $5 million gift from the Edward P. Evans Foundation will create the Edward P. Evans Center for Myelodysplastic Syndromes (MDS) at Dana-Farber Cancer Institute. The gift will help Dana-Farber in transformative collaborative research aimed at treating, preventing, and ultimately curing MDS....
FDA Issues Drug Safety Communication on Lung Inflammation Linked to Treatment With CDK4/6 Inhibitors
On September 13, the U.S. Food and Drug Administration (FDA) issued a drug safety communication warning that palbociclib, ribociclib, and abemaciclib—used to treat some patients with advanced breast cancer—may cause rare but severe inflammation of the lungs. The agency approved new warnings about...
Friends of Cancer Research Hosts Annual Leadership Awards
On September 24, 2019, Friends of Cancer Research (Friends) hosted its 23rd Annual Cancer Leadership Awards Reception. The event honored individuals who have been champions of cancer research and steadfast advocates for patients: Anna Barker, MA, PhD, Professor and Director, Transformative...
Zanetta Lamar, MD, Joins Florida Cancer Specialists
Florida Cancer Specialists & Research Institute (FCS) welcomes Zanetta Lamar, MD, to the statewide practice. She is practicing medical oncology and hematology in the Naples Goodlette office. After earning her medical degree with honors from Meharry Medical College in Nashville, Dr. -Lamar...
ASTRO Honors 2019 Gold Medalists, Honorary Member, and Other Award Recipients
The American Society for Radiation Oncology (ASTRO) recognized the recipients of its 2019 Gold Medal awards and other high-profile honors at the 2019ASTRO Annual Meeting in Chicago. Gold Medalists Walter J. Curran Jr, MD; Silvia C. Formenti, MD, FASTRO; and Thomas R. Mackie, PhD, were awarded the...
$5 Million Gift to Advance Ovarian Cancer Research
The chairman emeritus of The Estée Lauder Companies has made a $5 million gift to the University of Arizona Cancer Center. The gift from Leonard A. Lauder supports the clinical and translational research of David S. Alberts, MD, an expert in the field of ovarian cancer research and treatment. Dr....
FDA Pipeline: Treatments for HER2-Positive Breast Cancer, AML; Breakthrough Device for Prostate Cancer; Statement on Safety Information for Breast Implants
Recently, the U.S. Food and Drug Administration (FDA) granted Priority Review to trastuzumab deruxtecan for the treatment of HER2-positive metastatic breast cancer; granted Fast Track designation for bemcentinib for elderly patients with relapsed acute myeloid leukemia (AML); granted Breakthrough...
A Clinical Trial Was the Right Choice for Me
Nothing prepared me for a diagnosis of diffuse large B-cell lymphoma (DLBCL) in the fall of 2016. I had none of the typical symptoms of the cancer, such as night sweats, enlarged lymph nodes, or fatigue. In fact, my energy level was as high as ever, as I traveled around the country for business,...
Salk Scientist Tony Hunter, PhD, Receives National Cancer Institute Outstanding Investigator Award
Tony Hunter, PhD, a British-American biologist who is a Professor of Biology at the Salk Institute for Biological Studies, has received a National Cancer Institute (NCI) Outstanding Investigator Award, which supports accomplished leaders in cancer research. He will receive more than $7,500,000...
FDA Approves Niraparib for Patients With Homologous Recombination Deficiency–Positive Advanced Ovarian Cancer
On October 23, the U.S. Food and Drug Administration (FDA) approved niraparib (Zejula) for patients with advanced ovarian, fallopian tube, or primary peritoneal cancer treated with three or more prior chemotherapy regimens and whose cancer is associated with homologous recombination...
Susan G. Komen Strengthens Advocacy Efforts With Launch of Komen Center for Public Policy
Susan G. Komen recently unveiled the Susan G. Komen Center for Public Policy, which is part of the organization’s growing efforts to fight for the interests of those impacted by breast cancer among state and federal policymakers. Through the Center, Komen will educate and mobilize breast cancer...
Health Insurance Literacy and Financial Hardship in Cancer Survivors
A new study published by Zhao et al in JNCI Cancer Spectrum has linked health insurance literacy with medical financial hardship as well as nonmedical financial sacrifices among adult cancer survivors in the United States. The study’s authors say the study indicated that health insurance literacy...
Two New $1 Million Research Grants Focus on Metastasis of Melanoma
The American Cancer Society and Melanoma Research Alliance have selected two new promising projects in a second round of funding under a partnership between the two organizations. The first grants funded through the partnership, in 2018, focused on advancing research to reduce side effects...
National Clinical Trials Consultant, Linda L. Hogan, Dies at Age 72
Linda L. Hogan died on August 30, 2019, following a 25-year history of living with breast cancer and a more recent diagnosis of advanced lung cancer. She was born on November 29, 1946, in Farmington, Maine, and was the only child of Eleanor Sidell (Hogan) Stevens of Madison/Waterville, Maine, and...
Applying Results From CALGB (ALLIANCE)/SWOG 80405 Study
A recent study1 finding significantly longer progression-free survival and reduced risk for treatment-related toxicities among patients with metastatic colorectal cancer being treated with chemotherapy can have immediate application, albeit with some caveats related to the observational nature of...
Physical Activity Delays Disease Progression and Lowers Risk of Adverse Events in Patients With Metastatic Colorectal Cancer
Patients who were being treated with chemotherapy for metastatic colorectal cancer and who reported engaging in physical activity had a significantly longer progression-free survival and reduced risk for treatment-related adverse events than did those reporting less physical activity, according to...
The Art of Medicine: Our Role as Patient Advocates
The ASCO Post is pleased to reproduce installments of the Art of Oncology as published previously in the Journal of Clinical Oncology. These articles focus on the experience of suffering from cancer or of caring for people diagnosed with cancer, and they include narratives, topical essays,...
