Robert L. Ferris, MD, PhD, a head and neck surgical oncologist, has been named the Executive Director of the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center and UNC System Chief of Oncology Services, effective October 1, announced the Dean of the UNC School of Medicine Wesley Burks, MD.
Robert L. Ferris, MD, PhD
Dr. Ferris comes to UNC from the University of Pittsburgh Medical Center (UPMC), where he was the Director of the Hillman Cancer Center. He succeeds Shelley Earp, MD, who served as UNC Lineberger Director twice—from 1997 to 2014, and 2018 to 2024. Dr. Earp announced his intent to step down as Director last fall. He will continue as a faculty member of UNC School of Medicine and the cancer center; to lead his lab at UNC Lineberger; and his service to external organizations, including as Chair of the National Cancer Institute’s Board of Scientific Advisors.
“[Dr.] Ferris is an exceptional cancer physician-scientist, a highly skilled health executive with deep experience leading a National Cancer Institute (NCI)-[designated] comprehensive cancer center, and a person with a genuine passion for service to others,” said Dr. Burks, Vice Chancellor for Medical Affairs at UNC School of Medicine and Chief Executive Officer of UNC Health. “This blend of skills, experience, and vision makes [Dr. Ferris] the ideal person to lead our cancer center and to expand on the leadership successes of [previous leaders], under whose direction UNC Lineberger has become one of our country’s great cancer centers.”
The appointment marks a return to Chapel Hill for Dr. Ferris, who earned his bachelor’s degree in chemistry with honors and distinction from UNC-Chapel Hill. He earned his medical degree and his PhD in immunology from Johns Hopkins Medical School, where he also completed his residency, and was Chief Resident in otolaryngology/head and neck surgery.
Dr. Ferris has served as Director and Associate Senior Vice Chancellor for Cancer Research at UPMC Hillman Cancer Center since 2017, and Senior Vice President for Oncology Programs at UPMC and Associate Senior Vice Chancellor for Cancer Research at the University of Pittsburgh starting in 2023. Under his leadership, UMPC Hillman’s clinical, academic, and research faculty and activities were more closely aligned. This, among other things, generated a 29% increase in peer-reviewed cancer research funding ($106 million, up from $82 million) and a 53% increase in NCI funding ($48 million, up from $31.2 million). The center also obtained or renewed three highly sought-after NCI Specialized Programs of Research Excellence (SPORE) research grants (in head and neck, skin, and ovarian cancers), and multiple principal investigator grants.
Dr. Ferris has also led a highly productive clinical, translational, and laboratory research enterprise during his tenure at Hillman Cancer Center, which led to the founding of two companies and the publication of more than 450 peer-reviewed scientific papers and book chapters.
He has been the principal investigator of multiple cancer immunotherapeutic trials, including several studies investigating treatment deintensification for human papillomavirus-associated head and neck cancer after transoral surgery. He is the principal investigator of the Specialized Programs of Research Excellence in head and neck cancer. His translational research has generated fundamental insights into the mechanisms of antitumor immunity in the tumor microenvironment and tumor cell escape. His lab pioneered studies demonstrating innate and adaptive immune responses induced by the EGFR-specific monoclonal antibody cetuximab in head and neck cancer. The team is also investigating immunosuppressive molecules including immune checkpoint receptors PD-1, CTLA-4, TIM-3, and LAG-3.
Dr. Ferris also had a longstanding commitment to external service. He co-chaired the NCI Steering Committee for Head and Neck Cancer and is the Immediate Past President of the American Head and Neck Society. He serves on the external advisory boards for The University of Texas MD Anderson Cancer Center, the University of Pennsylvania Abramson Cancer Center, and the Georgetown Lombardi Cancer Center. He also is the Editor-in-Chief of the journal Oral Oncology and is on the editorial boards for the publications Clinical Cancer Research and Cancer Immunology Research.
