Maximiliano D’Angelo, PhD, Assistant Professor at Sanford Burnham Prebys Medical Discovery Institute, has received a 4-year, $792,000 Research Scholar Grant from the American Cancer Society (ACS). The ACS awards Research Scholar Grants for promising research projects that may lead to the elimination of cancer as a major health problem. Recipients must be in the first 6 years of an independent research career or faculty appointment.
Dr. D’Angelo, who has been at Sanford Burnham Prebys Medical Discovery Institute since 2014, will use the grant to study how alterations in nuclear pore complexes contribute to the malignant transformation of blood cells and cancer. Nuclear pore complexes play an important role in exchanging molecules between the cell nucleus and cytoplasm, as well as in the organization and regulation of cell processes. Alterations in certain proteins that comprise nuclear pore complexes have been detected in cancer, especially in several types of leukemia.
“I’m very grateful to the ACS for supporting this research,” said Dr. D’Angelo. “There is a tremendous need to understand the pathways leading from nuclear pore complex defects to cancer—insights that may lead to better treatments and potentially cures.” ■