Pediatric Regimen Yields Improved Survival for Adults With ALL

Arisk-stratified analysis of the Nordic Society for Pediatric Hematology and Oncology (NOPHO) protocol ALL2008 showed almost identical outcomes in adults and children aged 1 to 45 years with Philadelphia-negative acute lymphoblastic leukemia (ALL). Nina Toft, MD, of the Herlev University Hospital in Denmark, reported findings from the analysis at the European Hematology Congress in Copenhagen.¹

The event-free survival for ALL patients 18 to 45 years improved to 73% from 40% following implementation of the NOPHO ALL2008 protocol in July 2008. The intensive protocol, dividing patients into four risk groups depending mainly on response to treatment, is now used for ALL patients 1 to 45 years in Denmark, Norway, Sweden, Finland, Iceland, Lithuania and Estonia. ■

Reference

1. Toft N: Adults and children (1 to 45 years) with PH-negative ALL have almost identical outcome in risk-stratified analysis of NOPHO ALL2008. Abstract LB173. European Hematology Association Congress. Presented June 10, 2016.