Pediatric CT Scans and Subsequent Malignancy Risk

Key Points

  • Overall cancer incidence was 1.5 times higher than expected.
  • For all brain tumors combined and for malignant and nonmalignant brain tumors separately, dose-response relationships were observed with radiation dose to the brain.
  • The researchers observed no association with leukemia.

A new study by Meulepas et al in the Journal of the National Cancer Institute suggests that computed tomography (CT) scans may increase the risk of brain tumors.

The use of CT scans has increased dramatically over the past 2 decades. CT scans greatly improve diagnostic capabilities, which improves clinical outcomes, but they deliver higher radiation doses than other tests. Therefore, radiation protection is a concern, especially among children, who may receive higher radiation doses, are more susceptible to radiation-related malignancies than adults, and have a longer time to show effects from the potential risk.

The most common malignancies caused by radioactivity among children and young adults are leukemia and brain tumors. Researchers therefore evaluated leukemia and brain tumor risks following exposure to radiation from CT scans in childhood.

For a nationwide group of 168,394 Dutch children who received one or more CT scans between 1979 and 2012, researchers obtained cancer incidence and vital status by record linkage. They surveyed all Dutch hospital-based radiology departments to ascertain eligibility and participation. In the Netherlands, pediatric CT scans are only performed in hospitals.

Study Findings

Overall cancer incidence was 1.5 times higher than expected. For all brain tumors combined and for malignant and nonmalignant brain tumors separately, dose-response relationships were observed with radiation dose to the brain. Relative risks increased to between two and four for the highest dose category.

The researchers observed no association with leukemia. Radiation doses to the bone marrow, where leukemia originates, were low.

The researchers caution that this pattern of excess cancer risk may be partly due to confounding by indication, because the incidence of brain tumors was higher in the cohort than in the general population. CT scans are sometimes used to identify conditions associated with an increased tumor risk; the reason these children had CT scans may be associated with their risk of developing cancer.

“Epidemiological studies of cancer risks from low doses of medical radiation are challenging,” said principal investigator Michael Hauptmann, PhD, of the Netherlands Cancer Institute. “Nevertheless, our careful evaluation of the data and evidence from other studies indicate that CT-related radiation exposure increases brain tumor risk. Careful justification of pediatric CT scans and dose optimization, as done in many hospitals, are essential to minimize risks.”

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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