ASCO 2018: Updated ALEX Trial Results on Alectinib in Treatment-Naive ALK Mutation–Positive NSCLC

Key Points

  • At 10.9 months, half of the cancers treated with crizotinib had restarted their growth, whereas it took 34.8 months for patients on alectinib to reach this same median progression-free survival.
  • The progression-free survival was almost identical in patients without brain metastases at the point of diagnosis.
  • Additionally, 45% of patients treated with crizotinib went on to develop brain metastases while on trial, compared with only 12% of patients treated with alectinib.
  • The overall response rate for alectinib was 82.9%, compared with 75.5% for crizotinib.

Updated results of the global phase III ALEX trial comparing alectinib (Alecensa) with crizotinib (Xalkori) as first-line treatment against ALK-positive non–small cell lung cancer (NSCLC) show a median progression-free survival of 34.8 months in 152 patients treated with alectinib vs 10.9 months in 151 patients treated with crizotinib. These findings were presented by Camidge et al at the 2018 ASCO Annual Meeting (Abstract 9043).

“Think of it like a horse race, only it’s not about who crosses the finish line first, but how far the horses can run,” said D. Ross Camidge, MD, PhD, the Joyce Zeff Chair in Lung Cancer Research at the University of Colorado Cancer Center, Director of Thoracic Oncology at the CU School of Medicine, and the study’s first author. “In this trial, it’s as if half of the people ‘riding’ crizotinib had exhausted their horses at about 11 months. For patients on alectinib, when this trial first started reporting data last year, more than half were still on their horses, still running. Now enough time has elapsed to estimate the median performance of these alectinib ‘horses’ more accurately.”

More on the New Data

Dr. Camidge’s analogy explains the results above: At 10.9 months, half of the cancers treated with crizotinib had restarted their growth, whereas it took 34.8 months for patients on alectinib to reach this same median progression-free survival. The progression-free survival was almost identical in patients without brain metastases at the point of diagnosis, demonstrating the drug’s success in broad overall cancer control.

“When preliminary data were reported last year, estimates were looking to be more like 25 months [of] progression-free survival on alectinib, so this jump to 34.8 months is huge and may surprise people,” Dr. Camidge said. “In reality, it’s just that patients’ progression tends to be rather sparse around the time of the 50% point, and when that happens, the median can jump around a lot.”

Additionally, 45% of patients treated with crizotinib went on to develop brain metastases while on trial, compared with only 12% of patients treated with alectinib. The overall response rate for alectinib was 82.9%, compared with 75.5% for crizotinib. Alectinib was also associated with fewer overall side effects than crizotinib, with 16% of alectinib patients requiring dose reduction and 22% requiring dose interruption, compared with 21% and 25% of crizotinib patients, respectively.

“Last year, when the data were presented, the risk of progression or death—the ‘hazard ratio’—of alectinib was reported as 47% of what it was on crizotinib, and now we show that the risk of progression or death for patients on alectinib was even lower, just 43% that of patients on crizotinib,” said Dr. Camidge.

Mechanism of Action

Both drugs target lung cancers in which the gene ALK becomes improperly fused with a partner gene, such as EML4, to code for a protein made from bits of both genes. These ALK fusion proteins have been shown to drive about 4% of all lung cancers, resulting in about 12,000 diagnoses of ALK-positive NSCLC in the United States every year.

Crizotinib earned U.S. Food and Drug Administration approval in 2011 to treat advanced ALK-positive lung cancer. Now, next-generation ALK inhibitors such as alectinib, which have shown activity post-crizotinib, are replacing or vying to replace crizotinib in many settings. In Dr. Camidge’s opinion, these updated data further consolidate alectinib as the standard-of-care for first-line treatment of ALK mutation­–positive NSCLC.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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