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supportive care

ASCO Releases Guideline on Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers

The American Society of Clinical Oncology has released a clinical practice guideline on prevention and treatment of chemotherapy-induced peripheral neuropathy in adult cancer patients, published in the Journal of Clinical Oncology. The overall incidence of chemotherapy-induced peripheral neuropathy ...

solid tumors
supportive care

Consumptive Hypothyroidism in GIST Associated With Increased D3 Expression

In a report in The New England Journal of Medicine, Maynard et al discuss identification of consumptive hypothyroidism due to overexpression of thyroid hormone–inactivating enzyme type 3 iodothyronine deiodinase (D3) in a patient with gastrointestinal stromal tumor (GIST) and subsequent...

lung cancer
supportive care

Experts Call for More Awareness of Sexual Dysfunction in Lung Cancer Patients

Many lung cancer patients suffer difficulties with sexual expression and intimacy, yet for too long the topic has been ignored by doctors and researchers, experts said at the 4th European Lung Cancer Conference (ELCC) in Geneva, Switzerland. Researchers have estimated that sexual dysfunction...

supportive care
survivorship

NCCN Cancer Survivorship Guidelines Expanded to Address Two Common Conditions

The National Comprehensive Cancer Network (NCCN) has expanded its Survivorship Guidelines to include a section on cancer-associated cognitive impairment, and to include chemotherapy-induced peripheral neuropathy as a component of the Adult Cancer Pain section. The inaugural guidelines for...

breast cancer
supportive care
survivorship

Epigenetic Imprint of Chemotherapy Linked to Inflammation in Breast Cancer Survivors

Many breast cancer survivors experience fatigue and other debilitating symptoms that persist months to years after their course of treatment has ended. Now researchers at the Winship Cancer Institute of Emory University have found clues that may explain how these symptoms can linger. Chemotherapy...

supportive care
issues in oncology

Study Finds More Hospital Deaths and Invasive Care for Terminal Cancer Patients Receiving Palliative Chemotherapy

Patients with terminal cancer who receive chemotherapy during the last months of their lives are less likely to die where they want and more likely to endure invasive medical procedures than those who do not receive chemotherapy, according to a study by Wright et al published in BMJ. The findings...

supportive care

Early Palliative Care Benefits Patients With Advanced Cancer

In a study published in The Lancet, Zimmermann et al compared quality of life, symptom severity, and care satisfaction with early initiation of palliative care vs standard cancer care in patients with advanced cancer. Although early palliative care was not associated with improved quality of life...

head and neck cancer
supportive care

Daily Humidification of the Mouth and Throat During Radiation for Head and Neck Cancer Reduces Mucositis

New study findings show that patients with head and neck cancer receiving daily humidification of the mouth and throat during radiation therapy had reduced symptoms of muscositis and spent nearly 50% fewer days in the hospital to manage their treatment side effects. The study by Macann et al was...

colorectal cancer
supportive care

Coordination of Care Improves Patient-Reported Quality of Supportive Care Among Patients With Colorectal Cancer

In a study reported in the Journal of Clinical Oncology, van Ryn et al assessed patient-reported quality of care among patients with colorectal cancer in the Veterans Affairs health-care system. The investigators found significant gaps in patient-centered quality of supportive care, but also found...

kidney cancer
supportive care

Expressive Writing Improves Symptoms and Physical Function in Patients With Renal Cell Carcinoma

In a trial reported in the Journal of Clinical Oncology, Milbury et al compared cancer symptoms, physical and mental function, depressive symptoms, fatigue, and sleep outcomes after sessions of expressive writing about cancer vs writing about neutral topics in patients with renal cell carcinoma....

breast cancer
supportive care
survivorship
integrative oncology

Yoga Improves Inflammation, Fatigue, and Vitality in Breast Cancer Survivors

In a study reported in the Journal of Clinical Oncology, Kiecolt-Glaser et al found that yoga reduced levels of inflammatory cytokines and fatigue and increased vitality in breast cancer survivors. Study Details In the study, 200 women with stage 0 to IIIA breast cancer who had completed...

breast cancer
supportive care

Cognitive-Behavioral Therapy Plus Hypnosis Controls Fatigue in Breast Cancer Patients Receiving Radiotherapy

In a study reported in the Journal of Clinical Oncology, Montgomery et al found that an intervention consisting of cognitive-behavioral therapy plus hypnosis produced better control of fatigue than supportive meetings with trained interventionists for women undergoing radiotherapy for breast...

supportive care

Both Mindfulness-Based Stress Reduction and, More So, Cognitive Behavioral Therapy Improve Insomnia in Cancer Patients

In a noninferiority trial reported in the Journal of Clinical Oncology, Garland et al compared the effects of mindfulness-based stress reduction vs cognitive-behavioral therapy for treatment of insomnia in patients with cancer. They found that both techniques improved insomnia, with...

supportive care

Short-Term Follow-up Reveals Suboptimal Pain Relief and Marked Pain Worsening in Ambulatory Cancer Patients

In an analysis reported in the Journal of Clinical Oncology, Zhao et al assessed factors associated with pain severity changes in ambulatory patients with solid tumors in the Eastern Cooperative Oncology Group E2Z02 (Symptom Outcomes and Practice Patterns) trial. They found that approximately...

supportive care

Nurse- and Gastroenterologist-Led Algorithm-Based Management Improve GI Symptoms After Pelvic Radiotherapy

In the ORBIT trial, reported in The Lancet, Andreyev et al compared outcomes with usual care, gastroenterologist-led algorithm-based management, and nurse-led algorithm-based management for patients with chronic gastrointestinal symptoms following pelvic radiotherapy for cancer. The findings...

supportive care

Web-Based Self-Care Support and Communication Coaching Program Reduces Symptom Distress in Cancer Patients

In the ESRA-CII trial reported in the Journal of Clinical Oncology by Berry et al, patient use of a Web-based self-care program featuring tailored education and communication coaching resulted in significantly reduced symptom distress compared with symptom/quality-of-life tracking alone in patients ...

supportive care
issues in oncology

Most Physicians Would Enroll in Hospice If They Were Terminally Ill With Cancer, Study Finds

In a research letter published in JAMA Internal Medicine, Chinn et al surveyed physicians’ attitudes towards hospice treatment if they were terminally ill with cancer and assessed how physician preferences might affect timing of hospice discussions with their terminally ill patients. They...

supportive care

Single Fractions of Radiation for Painful Bone Metastases May Be Noninferior to Multiple Fractions

Optimal dose fractionation for radiation therapy of painful bone metastases from multiple primary sites remains undefined. In a phase III noninferiority trial reported in The Lancet Oncology, Chow et al compared 8 Gy in a single fraction vs 20 Gy in multiple fractions in patients with painful bone...

breast cancer
supportive care

No Difference for Aprepitant vs Dexamethasone for Chemotherapy-Induced Delayed Emesis in Patients With Breast Cancer

In a phase III study reported in the Journal of Clinical Oncology, Roila et al compared aprepitant vs dexamethasone in prevention of delayed emesis in breast cancer patients treated with anthracycline/cyclophosphamide who had received palonosetron/aprepitant/dexamethasone prophylaxis for acute...

colorectal cancer
supportive care

No Benefit of Calcium/Magnesium in Preventing Oxaliplatin-Induced Sensory Neurotoxicity in Patients With Colon Cancer

In a phase III N08CB/Alliance trial reported in the Journal of Clinical Oncology, Loprinzi et al assessed whether calcium and magnesium treatment reduced oxaliplatin-related neurotoxicity in patients with colon cancer receiving adjuvant FOLFOX (fluorouracil, leucovorin, and oxaliplatin). They found ...

supportive care
survivorship

Internet-Based Intervention Improves Cancer-Related Sexual Dysfunction in Women

An Internet-based intervention may significantly improve both sexual function and satisfaction in women with sexual dysfunction years after treatment for breast or gynecologic cancer, according to a randomized trial reported in the November issue of the Journal of the National Comprehensive Cancer...

supportive care

Most Patients Experience Nocturnal Care Disturbances Following Hematopoietic Stem Cell Transplantation

In a study reported in the Clinical Journal of Oncology Nursing, Eileen Danaher Hacker, PhD, APN, AOCN, of the University of Illinois College of Nursing, and colleagues attempted to identify and quantify nocturnal care disruptions in patients undergoing hematopoietic stem cell transplantation. They ...

breast cancer
supportive care

Pegfilgrastim Prophylaxis Throughout Chemotherapy Is More Effective in Preventing Febrile Neutropenia in Breast Cancer (and More Costly)

Available data suggest that risk of febrile neutropenia is greatest during the first two cycles of chemotherapy in patients with breast cancer. In a study reported in the Journal of Clinical Oncology, Maureen J. Aarts of Maastricht University Medical Centre in the Netherlands, and colleagues...

hematologic malignancies
supportive care

Atorvastatin May Prevent Graft-vs-Host Disease in Allogeneic Stem Cell Transplant Recipients

Because statins exhibit immunomodulatory and anti-inflammatory effects that may ameliorate graft-vs-host disease, they may be a safe strategy following allogeneic hematopoietic cell transplantation. In a phase II study reported in the Journal of Clinical Oncology, Mehdi Hamadani, MD, and colleagues ...

supportive care

Teenagers and Young Adults Diagnosed With Cancer Are at Increased Risk of Suicide

Teenagers and young adults are at increased risk of suicide after being diagnosed with cancer, according to a study published today in Annals of Oncology. A study of nearly 8 million Swedes aged 15 and over found that among the 12,669 young people diagnosed with cancer between the ages of 15 and...

supportive care
issues in oncology

Palliative Care Services and Outcomes Improve Using a Standardized Approach

Standardized criteria for initiating palliative care consultations can substantially improve the care of patients with advanced solid tumors, according to research from Mount Sinai School of Medicine, New York, led by Kerin Adelson, MD, Coordinator for Ambulatory Oncology Quality for the Tisch...

breast cancer
supportive care

High-Volume Aerobic and Resistance Exercise May Help Reduce Decline in Physical Function During Chemotherapy for Breast Cancer

In a Canadian study reported in the Journal of the National Cancer Institute, Kerry S. Courneya, PhD, of the University of Alberta, and colleagues assessed the impact of different levels of physical exercise on physical functioning in women receiving adjuvant chemotherapy for breast cancer....

supportive care

FDA Approves First Extended-Release, Single-Entity Hydrocodone Product

The U.S. Food and Drug Administration (FDA) today approved hydrocodone bitartrate extended-release capsules (Zohydro ER) for the management of pain severe enough to require daily, around-the-clock, long-term treatment and for which alternative treatment options are inadequate. The drug, a Schedule ...

prostate cancer
supportive care

No Additional Benefit of Venlafaxine or Soy Protein vs Placebo on Hot Flashes in Men With Prostate Cancer

Hot flashes occur in approximately 80% of androgen-deprived men. In a randomized study reported in the Journal of Clinical Oncology by Mara Z. Vitolins, DrPH, MPH, RD, of Wake Forest School of Medicine, and colleagues, neither venlafaxine nor soy protein—both of which have been used to...

prostate cancer
supportive care

Abiraterone Acetate/Prednisone Combination Delays Decline in Quality of Life in Men With Metastatic Prostate Cancer

According to a study published in The Lancet Oncology, abiraterone acetate (Zytiga) taken in conjunction with prednisone significantly delays progression of pain and quality of life deterioration in men with metastatic castration-resistant prostate cancer. The study was led by Ethan Basch, MD,...

supportive care

FDA Announces Class-Wide Safety Labeling Changes for Long-Acting Opioid Analgesics to Combat Abuse

The U.S. Food and Drug Administration (FDA) today announced class-wide safety labeling changes and new postmarketing study requirements for all extended-release and long-acting opioid analgesics intended to treat pain. “The FDA is invoking its authority to require safety labeling changes and ...

head and neck cancer
supportive care

Swallowing Exercises Preserve Function in Patients Receiving Radiation for Head and Neck Cancer

A study from UCLA's Jonsson Comprehensive Cancer Center (JCCC) has found that patients with head and neck cancer receiving radiation as part of their treatment were less likely to suffer unwanted side effects such as worsening of diet, need for a feeding tube, or narrowing of the throat passage if...

supportive care
issues in oncology

New Report Examines Trends in End-of-Life Care for Patients With Advanced Cancer

Although fewer Medicare patients with cancer died in the hospital in 2010 than in the years 2003–2007, aggressive treatment continues at the end of life, according to a new report from the Dartmouth Atlas Project. The findings also show that a significant number of patients were likely to...

head and neck cancer
supportive care

Many Patients With Head and Neck Cancer Report Being Depressed, But Few Use Mental Health Services

Despite a relatively high rate of depression among patients with head and neck cancer following radiation therapy, mental health services were severely underutilized in this group, concluded researchers who analyzed questionnaire results from 211 patients. The patients had been previously treated...

supportive care
integrative oncology

Yoga Improves Sleep Quality in Cancer Patients With Sleep Disruption

It is estimated that 30% to 90% of cancer patients experience impairment of sleep quality post-treatment and such impairment can be severe enough to increase morbidity and mortality. Preliminary evidence indicates that yoga may improve sleep in cancer patients. In a study reported in the Journal of ...

supportive care
integrative oncology

Integrative Medicine Interventions Found to Significantly Reduce Pain, Improve Quality of Life

An integrative approach to treating chronic pain significantly reduced pain severity and improved mood and quality of life, according to a new study from the Bravewell Practice-based Research Network (BraveNet) published in BMC Complementary and Alternative Medicine. Researchers found a reduction...

supportive care
integrative oncology

American Ginseng Improves Cancer-related Fatigue

In a collaborative phase III trial of the North Central Cancer Treatment Group and Mayo Clinic reported in Journal of the National Cancer Institute by Debra L. Barton, RN, PhD, of the Mayo Clinic, and colleagues, patients with cancer-related fatigue were treated with Wisconsin ginseng (a common...

multiple myeloma
supportive care

New Guidelines Issued in the Treatment of Multiple Myeloma–related Bone Disease

The International Myeloma Working Group (IMWG) has developed clinical practice recommendations for the management of multiple myeloma–related bone disease based on published study data through August 2012. Consensus of the interdisciplinary panel of clinical experts on the plasma-cell...

supportive care

Oral Apixaban Lowers Rates of Major Bleeding in Patients with Acute Venous Thromboembolism

Single-agent apixaban (Eliquis) may simplify the treatment of patients with acute venous thromboembolism, according to a new study published online in The New England Journal of Medicine. In the phase III AMPLIFY trial, the oral factor Xa inhibitor anticoagulant was found to be as effective as ...

breast cancer
supportive care
integrative oncology

Acupuncture May Reduce Arm Lymphedema in Patients with Breast Cancer

Arm lymphedema affects approximately 30% of breast cancer survivors, with rates increasing with longer follow-up and cases presenting well beyond the active treatment period. Lymphedema is observed even with use of less-invasive surgical techniques for staging, and risk is further increased by such ...

supportive care
issues in oncology

Majority of Patients with Incurable Lung Cancer Have Inaccurate Expectations about Goals of Radiation Therapy

Aileen B. Chen, MD, MPP, of Dana-Farber Cancer Institute and Brigham and Women’s Hospital, and colleagues in the Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium recently assessed patient expectations regarding goals of radiation therapy (RT) for incurable lung cancer. They ...

supportive care
issues in oncology

ASCO 2013: Adapting to Ongoing Shortages of Common Cancer Drugs

A survey of 214 U.S. oncologists and hematologists found that more than 80% encountered cancer drug shortages between March and September of 2012, and many reported that shortages affected the quality of patient care they were able to provide. As physicians were forced to substitute more expensive...

supportive care

New Labeling for Reformulated OxyContin to Curb Abuse

The U.S. Food and Drug Administration has approved updated labeling for the reformulated painkiller OxyContin (controlled-release oxycodone hydrochloride). The new labeling will indicate that the drug has physical and chemical properties that make injection or snorting challenging. This new measure ...

supportive care

Antidepressant Helps Relieve Pain from Chemotherapy, Study Finds

The antidepressant drug duloxetine (Cymbalta) helped relieve painful numbness and tingling feelings caused by chemotherapy in 59% of patients, a new study finds. This is the first clinical trial to find an effective treatment for this pain. Chemotherapy-induced peripheral neuropathy is a common...

supportive care

UC Davis Research Advances Efforts to Prevent Venous Thromboembolism

New research from the UC Davis Comprehensive Cancer Center, published in the Journal of Surgical Research, may help clinicians determine which patients are at highest risk for postsurgical blood clots in the legs or lungs. A team led by Robert J. Canter, MD, Associate Professor of Surgery at UC...

supportive care
survivorship

Study Shows Confidence Builds Better Exercise Habits for Cancer Survivors

Endometrial cancer survivors are more likely to complete physical activity, and for longer durations, when their daily self-efficacy is higher, according to a study published online in the journal Health Psychology, a publication of the American Psychology Association. “Sedentary behavior is ...

supportive care

Involving Other Providers in Palliative Care May Help Meet Growing Demand

As baby boomers age and the number of people with serious chronic illnesses continues to rise, the demand for experts in palliative medicine is sure to outstrip the supply, according Timothy E. Quill, MD, Professor of Medicine, Psychiatry and Medical Humanities in the Center for Ethics, Humanities...