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pancreatic cancer
issues in oncology

Daily Low-Dose Aspirin Use May Reduce Risk of Developing Pancreatic Cancer

Men and women who took low-dose aspirin regularly had a 48% reduction in their risk of developing pancreatic cancer, according to a new study. In addition, the longer a person started taking low-dose aspirin, the greater the benefit, ranging from 48% reduction in people who started 3 years before...

pancreatic cancer

Priming Pancreatic Cancer Cells With a Vaccine May Allow Them to Respond to Immunotherapy

Pancreatic ductal adenocarcinoma is considered a “nonimmunogenic” neoplasm and does not typically respond to immunotherapy, in part due to a complex tumor microenvironment that provides a formidable barrier to immune infiltration and function. A new study by Lutz et al has found that by ...

pancreatic cancer

Central Pancreatectomy for Low-Grade Neoplasms Results in 'Excellent' Pancreatic Function but Substantial Morbidity

The availability of cross-sectional imaging has resulted in increased diagnosis of low-grade pancreatic neoplasms and use of central pancreatectomy as an alternative to standard resection for such lesions. In a French single-center experience reported in JAMA Surgery, Goudard et al found that...

pancreatic cancer
issues in oncology

Gene Mutation Found for Aggressive Form of Pancreatic Cancer

Researchers have identified a mutated gene common to adenosquamous carcinoma tumors, the first known unique molecular signature for this rare, but particularly virulent, form of pancreatic cancer. The findings by Liu et al are published in Nature Medicine. Pancreatic cancer is the fourth leading...

pancreatic cancer

Supportive Tumor Tissue Surrounding Cancer Cells Hinders Pancreatic Cancer Progression, Preclinical Study Reports

Fibrous tissue long suspected of making pancreatic cancer worse actually supports an immune attack that slows tumor progression but cannot overcome it, scientists at The University of Texas MD Anderson Cancer Center reported in the journal Cancer Cell. “This supportive tissue that’s...

pancreatic cancer

Early Study Shows Improved Survival With Radioimmunotherapy/Gemcitabine Combination in Patients With Advanced Pancreatic Ductal Cancer

A randomized phase Ib study of a combination of low radiosensitizing doses of gemcitabine and fractionated doses of 90Y-clivatuzumab tetraxetan in patients with metastatic pancreatic ductal cancer who had received at least two prior systemic therapies, has found a significant survival advantage in...

pancreatic cancer

Blocking CD47 Signals May Offer New Therapeutic Approach in the Treatment of Pancreatic Cancer

Two preclinical studies of tumor samples taken from 39 patients with pancreatic neuroendocrine tumors and 39 patients with pancreatic ductal adenocarcinoma has found that for both these pancreatic cancers, CD47 is expressed at elevated levels on the cells that make up the bulk of the tumors and on...

pancreatic cancer

Surgical Resection Is Underutilized in Patients With Early-Stage Pancreatic Cancer, Study Finds

Despite the benefits of surgery for early-stage pancreatic cancer, it remains underutilized for patients with this deadly disease, according to a new national analysis of trends and outcomes. Physician-scientists at University Hospitals (UH) Case Medical Center and Case Western Reserve University...

pancreatic cancer

Lab Study Finds Pancreatic Cancer Growth Is Slowed by Blocking the Hhat Enzyme

The overexpression of Hedgehog family proteins contributes to the development of many cancers. Research by Konitsiotis et al has found that blocking the function of the Hedgehog acyltransferase (Hhat) enzyme slows the growth and spread of pancreatic cancer. Targeting inhibition of the Hedgehog...

pancreatic cancer

Study Finds CT Scans Predict Chemotherapy Response in Pancreatic Cancer

Computed tomography (CT) scans routinely taken to guide the treatment of pancreatic cancer may provide an important secondary benefit. According to new research published in the Journal of Clinical Investigation by Koay et al, the scans also reflect how well chemotherapy will penetrate the tumor,...

gynecologic cancer
pancreatic cancer
solid tumors

Novel Cancer Vaccine Shows Promise in Ovarian Cancer and Mesothelioma

A novel approach to cancer immunotherapy may provide a new and cost-effective strategy against ovarian cancer and mesothelioma. In a study published in the Journal of Hematology & Oncology, Yuan et al reported that a fusion protein engineered to combine a molecule targeting a tumor-cell-surface ...

issues in oncology
pancreatic cancer

Proteomic Mucin Profiling More Accurate Than Cytology and CEA in Identifying Cystic Precursors of Pancreatic Cancer

Pancreatic cystic lesions are frequently detected radiologic incidentalomas, a considerable proportion of which are pancreatic cancer precursors. In a study reported in the Journal of the National Cancer Institute, Jabbar et al found that proteomic mucin profiling of cyst fluid was more accurate...

issues in oncology
pancreatic cancer

Researchers Identify Biomarker for Noncancerous Pancreatic Cysts

Researchers at the Indiana University School of Medicine have discovered a highly accurate, noninvasive test to identify benign pancreatic cysts, which could spare patients the cost and risk of surveillance or potentially dangerous surgical intervention. The findings are reported in the Journal of...

pancreatic cancer

Immunotherapy Strategy Boosts Survival in Metastatic Pancreatic Cancer

Overall survival was improved in patients with metastatic pancreatic cancer through an innovative immunotherapy strategy in a multicenter study to be reported at the 2014 Gastrointestinal Cancers Symposium (Abstract 177). The results were announced at a press briefing prior to the meeting....

cns cancers
pancreatic cancer

Combination Capecitabine/Temozolomide Appears Highly Effective in Patients With Treatment-Resistant Neuroendocrine Tumors

Interim results from an ongoing phase II clinical trial in patients with various types of advanced neuroendocrine tumors show that a new chemotherapy combination of capecitabine and temozolomide either stalled disease progression or shrank tumors in 95% of patients whose disease worsened after...

issues in oncology
pancreatic cancer

Low hENT1 Is Associated With Poorer Survival in Patients With Pancreatic Cancer Receiving Adjuvant Gemcitabine

In a study reported in the Journal of the National Cancer Institute, Greenhalf et al analyzed the association between human equilibrative nucleoside transporter 1 (hENT1) levels and survival in patients with pancreas cancer receiving adjuvant gemcitabine or fluorouracil (5-FU)/leucovorin after ...

pancreatic cancer

U.S. Pancreatic Cancer Death Rates Increasing in White Adults, Decreasing in Black Adults

In a study reported in Journal of the National Cancer Institute, Jiemin Ma, PhD, MHS, and colleagues from the American Cancer Society investigated trends in pancreatic cancer death rates in the United States between 1970 and 2009. They found that death rates have been increasing in white men and...

pancreatic cancer

Addition of Nab-Paclitaxel to Gemcitabine Improves Survival in Previously Untreated Metastatic Pancreatic Cancer

In a phase III trial reported in The New England Journal of Medicine, Daniel D. Von Hoff, MD, of Translational Genomics Research Institute in Phoenix, and colleagues assessed the addition of nanoparticle albumin-bound (nab)-paclitaxel (Abraxane) to gemcitabine in patients with previously untreated...

pancreatic cancer

Investigational Antibody-Drug Conjugate May Provide New Treatment Option for Pancreatic Cancer Patients

Patients with pancreatic cancer may benefit from an investigational member of an emerging class of anticancer drugs called antibody-drug conjugates, according to preclinical results presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held October...

pancreatic cancer

Novel Drug Combinations Targeting Pathways Triggered by KRAS May Benefit Patients With Pancreatic Cancer

Two drug combinations that simultaneously block two major signaling pathways downstream of the protein KRAS, which is aberrantly active in most pancreatic cancers, may provide a new treatment option for patients with this disease, according to preclinical results presented at the AACR-NCI-EORTC...

pancreatic cancer

Long-Term Obesity Is Linked With Poorer Pancreatic Cancer Survival

Although multiple studies have shown that high body mass index (BMI) is associated with an increased risk of developing pancreatic cancer, few studies have evaluated the impact of BMI on survival and none have used prospectively collected data on BMI. Now a large prospective study by Brian M....

pancreatic cancer

Gemcitabine Improves Overall Survival Following Surgery for Pancreatic Cancer

Among patients with pancreatic cancer who had surgery for removal of the cancer, treatment with the drug gemcitabine for 6 months resulted in increased overall survival as well as disease-free survival, compared with observation alone, according to a study in published in the October 9 issue of...

pancreatic cancer

Meta-Analysis Suggests Fluorouracil or Gemcitabine Is Optimum Adjuvant Treatment for Pancreatic Cancer

A meta-analysis reported in The Lancet Oncologyby Wei-Chih Liao, MD, of National Taiwan University Hospital and colleagues indicates that fluorouracil (5-FU) or gemcitabine is optimal adjuvant therapy for pancreatic adenocarcinoma. Chemoradiation was associated with poorer survival and...

issues in oncology
lung cancer
pancreatic cancer

Molecular Marker Predicts Patients Most Likely to Benefit Longest From EGFR Inhibitors

Scientists at Johns Hopkins have identified a molecular marker called Mig6 that appears to accurately predict longer survival—up to 2 years—among patients being treated with the EGFR inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Results from the preliminary study were published ...

pancreatic cancer

FDA Approves Nab-Paclitaxel for Late-Stage Pancreatic Cancer

The U.S. Food and Drug Administration (FDA) today expanded the approved uses of paclitaxel protein-bound particles for injectable suspension, albumin-bound (nab-paclitaxel, Abraxane) to treat patients with late-stage pancreatic cancer. “Patients with pancreatic cancer are often diagnosed...

pancreatic cancer

Risk of Pancreatic Cancer May Be Reduced by Better Diet

In a study reported in the Journal of the National Cancer Institute, Hannah Arem, MHS, PhD, of the National Institutes of Health, and colleagues analyzed the association between quality of diet according to the 2005 Dietary Guidelines for Americans—Healthy Eating Index 2005...

pancreatic cancer

Researchers Identify Origin of Inflammation-Driven Pancreatic Cancer

Researchers at Mayo Clinic in Florida have revealed the process by which pancreatitis—chronic inflammation of the pancreas—morphs into pancreatic cancer. They say their findings point to ways to identify pancreatitis patients at risk of pancreatic cancer and to potential drug therapies...

pancreatic cancer

ASCO 2013: For Patients with Metastatic Pancreatic Cancer, Both Treatment and Survival Decrease with Advanced Age

A new study by researchers Fox Chase Cancer Center has identified a disconnect between clinical trials that look at new treatments for metastatic pancreatic cancer and the patient population most likely to be diagnosed with the disease. Clinical trials typically enroll, and base their findings on,...

issues in oncology
pancreatic cancer

Molecular Marker from Pancreatic 'Juices' Helps Identify Pancreatic Cancer

Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis, two disorders that are difficult to tell apart. A molecular marker obtained from pancreatic “juices” can identify almost all cases of pancreatic cancer, their...

breast cancer
gynecologic cancer
pancreatic cancer
prostate cancer

ASCO 2013: PARP Inhibitor Shows Activity in Pancreatic, Prostate Cancers among Patients Carrying BRCA Mutations

In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced pancreatic and prostate cancers. Results of the study, led by researchers ...

issues in oncology
breast cancer
gynecologic cancer
pancreatic cancer

Novel Drug Combination Showed Antitumor Activity in Patients with Incurable BRCA-deficient Cancers

When given sequentially, two orally available experimental drugs—sapacitabine and seliciclib—worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers, according to phase I data presented at the AACR Annual Meeting 2013, held in Washington, DC, April...

pancreatic cancer
issues in oncology

New Metabolite-based Diagnostic Test Could Help Detect Pancreatic Cancer Early

A new diagnostic test that uses a technique known as metabolomic analysis may be a safe and easy screening method that could improve the prognosis of patients with pancreatic cancer through earlier detection. Researchers examined the utility of metabolomic analysis as a diagnostic method for...

pancreatic cancer

Indiana University Researchers Earn $3.2 Million Grant to Develop, Improve Therapies for Pancreatic Cancer

Two Indiana University researchers have been awarded a multiyear, $3.2 million grant to develop and improve therapies for pancreatic cancer, the fourth leading cause of cancer death in the United States. Mark R. Kelley, PhD, Betty and Earl Herr Professor of Pediatric Oncology Research, and Melissa ...

pancreatic cancer

Nab-paclitaxel plus Gemcitabine Demonstrates Survival Advantage in Phase III Study of Patients with Advanced Pancreatic Cancer

Celgene International Sàrl announced on Tuesday that its phase III clinical trial of paclitaxel protein-bound particles for injectable suspension, albumin-bound (nab-paclitaxel, Abaraxane) in combination with gemcitabine in treatment-naive patients with metastatic pancreatic cancer...

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