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head and neck cancer

Black Patients With Salivary Gland Mucoepidermoid or Squamous Cell Carcinoma Have Poorer Disease-Specific Survival Than White Patients

In a retrospective study of salivary gland cancer survival reported in JAMA Otolaryngology Head & Neck Surgery, Russell et al found black patients with mucoepidermoid or squamous cell carcinoma have poorer disease-specific survival than white patients, with no difference being observed between...

head and neck cancer

Differences in Lifestyle Habits and Poorer Adherence to Radiation Therapy in Patients With HPV-Negative vs HPV-Positive Oropharyngeal Carcinoma

Different mechanisms of carcinogenesis and molecular characteristics have been proposed for human papillomavirus (HPV)-positive and HPV-negative oropharyngeal carcinomas, and better outcomes have been observed in patients with HPV-positive tumors. Some experts advocate classification of the two as...

head and neck cancer
solid tumors

No Difference in Disease-Free Survival but Less Steroid Dependence With Adrenal-Sparing Surgery vs Adrenalectomy in Pheochromocytoma

Molecular diagnosis and preventive surgery have been successful in preventing medullary thyroid cancer in patients with multiple endocrine neoplasia type 2 syndrome. In a retrospective population-based study reported in The Lancet Oncology, Castinetti et al found no difference in disease-free...

head and neck cancer

Sorafenib Improves Progression-Free Survival in Progressive Radioactive Iodine–Refractory Differentiated Thyroid Cancer

Patients with radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer have a poor prognosis. In the double-blind phase III DECISION trial reported in The Lancet, Brose et al found that sorafenib (Nexavar) increased progression-free survival in this setting. The...

head and neck cancer
supportive care

Doxepin Rinse Reduces Radiotherapy-Associated Oral Mucositis Pain in Patients With Head and Neck Cancer

In a phase III double-blind crossover trial (North Central Cancer Treatment Group [NCCTG] N09C6, Alliance for Clinical Trials in Oncology cooperative group) reported in the Journal of Clinical Oncology, Leenstra et al found that oral doxepin hydrochloride rinse significantly reduced...

skin cancer
head and neck cancer
skin cancer

Total Parotidectomy May Benefit Patients With Cutaneous Squamous Cell Carcinoma or Malignant Melanoma With Metastasis to the Parotid Superficial Lobe

The optimal extent of surgical resection is unclear in patients with parotid superficial lobe lymph node metastasis from cutaneous squamous cell carcinoma and malignant melanoma. In a single-institution retrospective review reported in JAMA Otolaryngology Head & Neck Surgery, Thom et al found...

head and neck cancer

Study Examines Protein Expression Biomarkers in HPV-Negative Squamous Cell Carcinomas of the Head and Neck

A quartet of proteins that play critical roles in cell replication, cell death, and DNA repair could lead to better targets for therapy against treatment-resistant head and neck squamous cell cancers. In a study presented this week at the American Association for Cancer Research (AACR) Annual...

head and neck cancer

Prognosis of HPV-Positive Head and Neck Cancer Varies According to Tumor Site

Patients with cancer of the throat and who are positive for the human papillomavirus (HPV) have a good prognosis, but until now the effect of being HPV-positive on the prognosis of tumors located elsewhere in the head and neck was unknown. A new study presented at the 33rd Conference of the...

head and neck cancer

Long-Term Use of Valproic Acid May Reduce the Risk of Head and Neck Cancer

The antiseizure medication and mood stabilizer valproic acid was associated with a significant reduction in head and neck cancer risk, according to a study recently published in Cancer. The large retrospective cohort study by Kang et al was conducted to evaluate the effects of the drug, a histone...

skin cancer
head and neck cancer

Cutaneous Melanoma and Papillary Thyroid Carcinoma: Mutual Increased Risk

In a study reported in JAMA Otolaryngology-Head & Neck Surgery, Oakley et al found that papillary thyroid cancer increases the risk of cutaneous malignant melanoma and vice versa. In addition, the investigators found that patients with both cancers have a high frequency of BRAF V600E mutation. ...

head and neck cancer

Intensity-Modulated Radiation Therapy Reduces PEG Tube Dependence and Severe Skin and Mucous Membrane Toxicity in Oropharyngeal Cancer

In a single-center experience reported in JAMA Otolaryngology-Head & Neck Surgery, Lohia et al found that intensity-modulated radiation therapy for oropharyngeal cancer reduces percutaneous endoscopic gastrostomy (PEG) tube dependence and severe skin and mucous membrane toxicity compared with...

head and neck cancer

Oropharyngeal Cancer Patients Report Benefit in Salivary Function With Reduction of Radiation Dose to Bilateral Submandibular Lymph Nodes

For head and neck cancer patients undergoing radiation therapy, a reduction in the amount of radiation treatment volume to the submandibular (level IB) lymph nodes resulted in better patient-reported salivary function, according to research presented today at the 2014 Multidisciplinary Head and...

head and neck cancer

Patients With Oropharyngeal Cancer Report Decreased Quality of Voice and Speech After Treatment

Patients with oropharyngeal cancer treated with combined chemotherapy and radiation therapy reported a decrease in their voice and speech quality for up to 1 year after the completion of treatment, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium....

head and neck cancer

Unilateral Radiotherapy for Advanced Tonsil Cancer Yields Favorable Outcome

New research suggests that it is safe to limit radiation therapy to lymph nodes on only one side of the neck for lateralized tonsil cancer. In addition, the study findings show that primary tumor location, rather than the amount of lymph node involvement on the tumor side of the neck, drives the...

head and neck cancer

Avoiding Radiation to Major Salivary Glands in Head and Neck Cancer Is Safe and Improves Quality of Life

New research is showing that sparing the contralateral submandibular gland during radiation therapy in the treatment of locally advanced head and neck cancer is technically feasible and safe even in advanced-stage, node-positive disease and base-of-tongue lesions. Limiting radiation to these major...

head and neck cancer

Study Finds Combining a Novel Biomarker With HPV Status Predicts Patient Outcome in Head and Neck Cancer

Using next-generation sequencing and the clinical data of patients with head and neck squamous cell carcinoma, researchers found that combining mutant-allele tumor heterogeneity as a biomarker with patients’ human papillomavirus (HPV) status provides a reliable predictor of patient survival....

head and neck cancer

Distant Metastases Occur Later and in More Subsites in Patients With HPV-Positive Squamous Cell Carcinoma of the Oropharynx

Patients with human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx had a longer time to development of distant metastasis after initial treatment, and had more metastatic sites in more atypical locations compared to HPV-negative patients, according to research presented...

head and neck cancer

HPV-Positive Oropharyngeal Cancer Associated With Higher Overall Survival Rate After Progression Than HPV-Negative Disease

A retrospective analysis of patients with oropharyngeal cancer with recurrence of disease after primary therapy in the Radiation Therapy Oncology Group (RTOG) studies 0129 and 0522 found that human papillomavirus (HPV)-positive patients had a higher overall survival rate than HPV-negative patients, ...

head and neck cancer
supportive care

Daily Humidification of the Mouth and Throat During Radiation for Head and Neck Cancer Reduces Mucositis

New study findings show that patients with head and neck cancer receiving daily humidification of the mouth and throat during radiation therapy had reduced symptoms of muscositis and spent nearly 50% fewer days in the hospital to manage their treatment side effects. The study by Macann et al was...

head and neck cancer

Obesity Linked to Poor Survival in Patients With Tongue Cancer

Cancer experts from Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College are collaborating to understand the link between obesity and cancer. Most recently, their research has yielded an interesting association: Obesity prior to diagnosis is associated with a fivefold increase...

head and neck cancer

Intensity-Modulated Radiation Therapy Improves Survival in Patients With Head and Neck Cancer

Patients with cancers of the head and neck who received intensity-modulated radiation therapy experienced improved outcomes, as well as reduced toxicities, compared to patients receiving conventional radiation therapy, according to findings published online in Cancer by Beadle et al. The study is...

head and neck cancer

Nonsignificant Survival Benefit With Postoperative Radiation Therapy for Head and Neck Cancer at Academic Center vs Other Institutions

In a study reported in JAMA Otolaryngology Head & Neck Surgery, George et al evaluated radiation treatment characteristics and outcomes among head and neck squamous cell carcinoma patients receiving adjuvant external-beam radiation therapy at an academic center vs other institutions....

head and neck cancer

Maintained Oral Intake and Swallowing Exercise Adherence During Radiation Therapy Improve Long-Term Swallowing Outcomes for Pharyngeal Cancer Patients

In a study reported in JAMA Otolaryngology Head & Neck Surgery, Hutcheson et al assessed the effects of maintained oral intake and adherence to swallowing exercises during radiation therapy or chemoradiation therapy for pharyngeal cancer. They found that both practices contributed independently ...

head and neck cancer

Postradiotherapy Neck Dissection Improves Local Control in Head and Neck Squamous Cell Carcinoma Patients With Advanced Nodal Disease

Available data indicate that lymph node involvement predicts failure at primary and distant sites after chemoradiation for head and neck cancer. In a study reported in JAMA Otolaryngology Head & Neck Surgery, Ranck et al assessed the impact of postradiotherapy neck dissection on local and...

head and neck cancer
issues in oncology

U.S. Preventive Services Task Force Issues Final Recommendations on Screening for Oral Cancer

The U.S. Preventive Services Task Force (USPSTF) today released its final recommendation statement on screening for oral cancer in adults without signs or symptoms of oral cancer who are seen by primary care providers. This recommendation focuses on primary care professionals and is not a...

head and neck cancer

Thyroid Ultrasound Strategy Identifies Low-Risk Patients Who Can Defer Biopsy

In a study reported in JAMA Internal Medicine, Smith-Bindman et al evaluated the ability of ultrasound imaging characteristics to determine risk of thyroid cancer associated with thyroid nodules. They found that a strategy of using two abnormal nodule characteristics as an indication for biopsy...

head and neck cancer

Certain Symptom Clusters After Surgery for Esophageal Cancer Predict Poor Prognosis

A new study has found that several months after surgery for esophageal cancer, different symptoms cluster together in different types of patients. In addition, patients with certain symptom clusters have an increased risk of dying from their disease. The findings by Wikman et al were published...

head and neck cancer

FDA Approves Sorafenib to Treat Late-Stage Differentiated Thyroid Cancer

The U.S. Food and Drug Administration today expanded the approved uses of sorafenib (Nexavar) to treat late-stage differentiated thyroid cancer. The new indication is for patients with locally recurrent or metastatic, progressive differentiated thyroid cancer that no longer responds to radioactive...

head and neck cancer

Increasing Proportion of Head and Neck Cancer Patients Treated at Teaching Hospitals

In a study reported in JAMA Otolaryngology Head & Neck Surgery, Neil Bhattacharyya, MD, of Brigham and Women’s Hospital and Harvard Medical School, and Elliot Abemayor, MD, PhD, of David Geffen School of Medicine at UCLA, analyzed recent patterns of hospitalization for head and neck...

head and neck cancer

Smoking Increases Risk of Death for Nasopharyngeal Carcinoma Survivors

Survivors of nasopharyngeal carcinoma who are former or current smokers are more likely to have their disease progress, relapse, or spread, and are more likely to die of their disease, compared with survivors of nasopharyngeal carcinoma who have never smoked, according to a study published in...

head and neck cancer

Basaloid Squamous Cell Carcinoma Not Predictive of Worse Outcome vs Squamous Cell Carcinoma in Head and Neck Cancer

In a study reported in JAMA Otolaryngology-Head & Neck Surgery, Okechukwu R. Linton, MD, MBA, of Indiana University School of Medicine, and colleagues assessed the prognostic significance of head and neck basaloid squamous cell carcinoma, which is considered a more aggressive form of squamous...

head and neck cancer

Increased Risk of Long-Term Cardiovascular Mortality and All-Cause Mortality in Patients With Differentiated Thyroid Carcinoma

In a study reported in the Journal of Clinical Oncology, Esther N. Klein Hesselink, of University Medical Center Groningen in the Netherlands, and colleagues evaluated long-term cardiovascular mortality in patients with differentiated thyroid cancer. They found that risk of cardiovascular and...

head and neck cancer

ASTRO: Intensity Modulated Proton Therapy May Preserve Quality of Life in Patients With Oropharyngeal Cancer

A new study from researchers at The University of Texas MD Anderson Proton Therapy Center found that the use of feeding tubes in patients with oropharyngeal cancer treated with intensity modulated proton therapy decreased by more than 50% compared to patients treated with intensity modulated...

head and neck cancer

Cabozantinib Improves Disease-Free Survival in Progressive Medullary Thyroid Cancer

Cabozantinib (Cometriq) is an inhibitor of hepatocyte growth factor receptor (MET), VEGFR2, and rearranged during transfection (RET) tyrosine kinases. In a phase III trial reported in Journal of Clinical Oncology, Rosella Elisei, MD, of the University of Pisa, and colleagues found that cabozantinib ...

head and neck cancer
supportive care

Swallowing Exercises Preserve Function in Patients Receiving Radiation for Head and Neck Cancer

A study from UCLA's Jonsson Comprehensive Cancer Center (JCCC) has found that patients with head and neck cancer receiving radiation as part of their treatment were less likely to suffer unwanted side effects such as worsening of diet, need for a feeding tube, or narrowing of the throat passage if...

head and neck cancer
issues in oncology
issues in oncology

High-Tech Imaging Contributes to Overdiagnosis, Overtreatment of Low-Risk Thyroid Cancers

A study from the Mayo Clinic Center for the Science of Health Care Delivery finds that advances in imaging technologies, including ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), are fueling an epidemic in the diagnosis and treatment of thyroid cancers that are unlikely...

head and neck cancer

More Prudent Interpretation of Thyroid Ultrasound Could Reduce Unnecessary Biopsies

Thyroid ultrasound imaging could be used to identify patients who have a low risk of thyroid cancer for whom biopsy could be deferred, according to a retrospective case-control study by Rebecca Smith-Bindman, MD, of the University of California, San Francisco, School of Medicine, and colleagues in...

head and neck cancer

Sorafenib Granted Priority Review for Differentiated Thyroid Cancer

Bayer HealthCare and Onyx Pharmaceuticals announced that the FDA has granted priority review designation to the supplemental new drug application of sorafenib (Nexavar) tablets for the treatment of locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer. The...

head and neck cancer
supportive care

Many Patients With Head and Neck Cancer Report Being Depressed, But Few Use Mental Health Services

Despite a relatively high rate of depression among patients with head and neck cancer following radiation therapy, mental health services were severely underutilized in this group, concluded researchers who analyzed questionnaire results from 211 patients. The patients had been previously treated...

head and neck cancer

Poor Oral Health Is an Independent Risk Factor for Cancer-Causing Oral HPV Infection

Poor oral health, including gum disease and dental problems, is a newly recognized independent risk factor for oral human papillomavirus (HPV) infection, which causes between 40% and 80% of oropharyngeal cancers, according to a study published in Cancer Prevention Research. Researchers from the...

head and neck cancer

Meta-Analysis Indicates Addition of Taxane to Cisplatin/5-FU Induction Improves Outcome in Locally Advanced Head and Neck Cancers

Cisplatin plus fluorouracil (5-FU) induction chemotherapy has been compared with taxane (docetaxel or paclitaxel), cisplatin, and 5-FU in randomized trials in locoregionally advanced head and neck cancers. An updated individual patient data meta-analysis reported in the Journal of Clinical Oncology ...

skin cancer
head and neck cancer

Omega-3 Fatty Acids May Aid in Treatment and Prevention of Skin and Oral Cancers

Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early- and late-stage oral and skin squamous cell carcinomas, according to new research from scientists at Queen Mary, University of London. The findings were published online...

gynecologic cancer
head and neck cancer
issues in oncology

CDC Report Shows Stagnated HPV Vaccination Rate for Girls

For the first time since the human papillomavirus (HPV) vaccine became available for adolescent girls in 2006, the vaccination rate for the teenagers has stalled, according to data published in the Centers for Disease Control and Prevention’s (CDC’s) Morbidity and Mortality Weekly...

gynecologic cancer
head and neck cancer
issues in oncology

HPV Vaccine Reduces Prevalence of Oral HPV Infections in Costa Rican Study

A new study by the International Agency for Research on Cancer (IARC), in partnership with Costa Rican investigators and the National Cancer Institute (NCI), shows for the first time that the vaccine against human papillomavirus (HPV) types 16 and 18, which is used to prevent cervical cancer, also...

head and neck cancer

Nomogram Accurately Predicts Salivary Gland Cancer Recurrence

Oncologists now have a new prognostic tool to help determine the risk of recurrence in patients with carcinoma of the major salivary glands and may help guide their post-treatment surveillance, according to study results published in JAMA Otolaryngology–Head & Neck Surgery. Researchers...

head and neck cancer

Addition of Panitumumab to Cisplatin/Fluorouracil Improves Progression-free Survival in Patients with Recurrent or Metastatic Head and Neck Cancer

Previous studies have shown that anti-EGFR monoclonal antibody treatment can improve clinical outcomes in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. In the open-label phase III SPECTRUM trial, Jan B. Vermorken, MD, of Antwerp University Hospital and...

head and neck cancer

Single Men, Smokers at Higher Risk for Oral HPV Infection

Smokers and single men are more likely to acquire oncogenic oral human papillomavirus (HPV), according to new results from the HPV Infection in Men (HIM) Study. Researchers from Moffitt Cancer Center, the National Cancer Institute, Mexico, and Brazil also reported that newly acquired oral HPV...

head and neck cancer

Increasing Incidence of Papillary Thyroid Cancer Linked to Overdiagnosis

The rapid increase in papillary thyroid cancer in the United States may not be linked to increase in occurrence, but instead may be linked to an increase in the diagnosis of precancerous conditions and to a person's insurance status, according to a study published online in Thyroid. "This [study]...

issues in oncology
head and neck cancer

Investigators Identify Promising Biomarker for Predicting HPV-related Oropharyngeal Cancer

Researchers have found that antibodies against the human papillomavirus (HPV) may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, In their study, at least one in three individuals with oropharyngeal cancer had antibodies to HPV, compared to...

head and neck cancer
head and neck cancer

ASCO 2013: Sorafenib Stalls Growth of Treatment-resistant Differentiated Thyroid Cancer

A randomized phase III study found that the targeted drug sorafenib (Nexavar) stalls disease progression by 5 months in patients with metastatic differentiated thyroid cancer that has progressed despite standard radioactive iodine therapy. If approved in this setting by the U.S. Food and Drug...

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