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head and neck cancer

Thyroid Cancer Rare in Patients With Asymptomatic Benign Nodules

A prospective, multicenter, observational study involving 992 consecutive patients with one to four asymptomatic, sonographically or cytologically benign thyroid nodules found that “the majority of nodules exhibited no significant size change during 5 years of follow-up or they actually...

breast cancer
head and neck cancer

New Analysis Reports Increased Risk of Thyroid Cancer After Breast Cancer Diagnosis

Breast cancer survivors are at increased risk of developing thyroid cancer, especially within 5 years of their breast cancer diagnosis, according to a new analysis of a large national database. The study results were presented at the Endocrine Society's 97th Annual Meeting. “Recognition of...

head and neck cancer

Improved TNM Prediction of Survival in HPV‑Related Oropharyngeal Carcinoma

In a study reported in the Journal of Clinical Oncology, Huang et al showed that recursive portioning analysis (RPA) could be used to provide TNM stage grouping with improved prediction of survival in patients with human papillomavirus (HPV)-related nonmetastatic oropharyngeal carcinoma. ...

head and neck cancer

FDA Approves Lenvatinib for Progressive Radioiodine-Refractory Differentiated Thyroid Cancer

The U.S. Food and Drug Administration (FDA) today granted approval to lenvatinib (Lenvima) to treat patients with progressive, differentiated thyroid cancer whose disease progressed despite receiving radioactive iodine therapy. Lenvatinib is a tyrosine kinase inhibitor that binds to multiple sites...

head and neck cancer

Lenvatinib Shows Promise for Patients With Radioiodine-Refractory Thyroid Cancer in Phase III Study

In a phase III study led by researchers at The University of Texas MD Anderson Cancer Center, the oral antiangiogenic therapy lenvatinib has shown dramatic improvement in progression-free survival in patients with advanced radioiodine-refractory thyroid cancer. Their findings are published by...

head and neck cancer

No Benefit of Panitumumab Plus Radiotherapy vs Cisplatin-Based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

In the phase II CONCERT-2 trial reported in The Lancet Oncology, Giralt et al found that treatment with the EGFR inhibitor panitumumab (Vectibix) plus concurrent radiotherapy was associated with poorer local-regional control vs cisplatin chemoradiation in previously untreated patients with...

head and neck cancer

No Benefit of Adding Panitumumab to Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

In the phase II CONCERT-1 trial reported in The Lancet Oncology, Mesía et al found that adding the EGFR inhibitor panitumumab (Vectibix) to standard cisplatin chemoradiation provided no benefit in previously untreated patients with unresected stage III to IVB head and neck squamous cell...

head and neck cancer

Dabrafenib May Stimulate Radioiodine Uptake in Patients With Iodine-Refractory Papillary Thyroid Cancer

In patients with iodine-refractory papillary thyroid cancer, the addition of dabrafenib (Tafinlar) therapy was shown to stimulate radioiodine uptake in thyroid cancer cells, according to a report by Rothenberg et al in Clinical Cancer Research. This approach has the potential advantage of requiring ...

head and neck cancer
issues in oncology

Study Uncovers Range of Molecular Alterations in Head and Neck Squamous Cell Carcinomas, New Potential Drug Targets

Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered genomic differences—with potentially important clinical implications—in human papillomavirus (HPV)-associated head and neck cancers. These findings were reported in Nature. The researchers also uncovered ...

head and neck cancer
issues in oncology

Head and Neck Cancers in Young Adults More Likely to Be a Result of Inherited Factors

Data from 25 case-control studies and separate analyses show that head and neck cancers in young adults are more likely to occur as a result of inherited factors rather than lifestyle factors, such as smoking or drinking alcohol, according to a new study by Toporcov et al published in the...

head and neck cancer

Oral Human Papillomavirus Infection More Likely to Persist in Older Men

Oral infection with human papillomavirus 16 (HPV16), which is the type of HPV most frequently linked to HPV-driven head and neck cancers, was more likely to persist 12 or more months in men older than 45 than in those younger than 45, according to a study reported by Pierce Campbell et al in...

head and neck cancer

Nonoperative Management Should Be Used With Caution in Patients With Small Papillary Thyroid Tumors

In a population-based study of patients with thyroid cancer, 12.3% of patients with small papillary thyroid tumors experienced thyroid cancer–related deaths despite undergoing thyroidectomy, according to a report by Nilubol and Kebebew in the journal Cancer. From the results of this study,...

head and neck cancer

Institutional Experience Significantly Affects Overall Survival in Locally Advanced Head and Neck Cancer

In a study reported in the Journal of Clinical Oncology, Wuthrick et al found that patients with stage III or IV head and neck cancer in the Radiation Therapy Oncology Group (RTOG) 0129 trial who were treated at historically high-accruing centers in RTOG clinical trials had significantly better...

head and neck cancer

RTOG 0129 Long-Term Results: No Differences in Survival or Toxicity With Accelerated vs Standard Fractionation Plus Cisplatin in Head and Neck Cancer

As reported in the Journal of Clinical Oncology by Nguyen-Tan et al, long-term follow-up in the phase III Radiation Therapy Oncology Group (RTOG) 0129 trial indicates no difference in overall survival or late toxicity with use of accelerated vs standard radiation therapy plus cisplatin in patients...

head and neck cancer

BRAF V600E Mutation Predicts Recurrence of Papillary Thyroid Cancer

In a large retrospective study reported in the Journal of Clinical Oncology, Xing et al found that presence of the BRAF V600E mutation was an independent predictor of recurrence of papillary thyroid cancer. The study involved 2,099 patients with papillary thyroid cancer consecutively selected over ...

head and neck cancer
skin cancer

Propensity Score–Matching Analysis Shows No Disease-Specific Survival Benefit of Sentinel Lymph Node Biopsy vs Observation in Head/Neck Melanoma

In a Surveillance, Epidemiology, and End Results (SEER) database analysis reported in JAMA Otolaryngology-Head & Neck Surgery, Sperry et al found that sentinel lymph node biopsy was not associated with improved disease-specific survival in propensity score–matched patients with head and...

head and neck cancer

Oral Cancer–Causing HPV May Be Transmitted Through Oral and Genital Contact

A study investigating the prevalence and risk factors of oral human papillomavirus (HPV) infection among young men has found a higher prevalence of oral HPV among men who had female partners with an oral and/or genital HPV infection, suggesting that transmission may occur through oral or genital...

head and neck cancer

Protein Linked With HPV-Positive Head and Neck Cancer May Lead to More Effective Therapies for the Disease

Scientists investigating the molecular mechanism of the protein p16 in cisplatin-treated head and neck cancer cells have found that the drug is able to kill the malignant cells by interacting with the protein gigaxonin. Although p16 is commonly produced in human papillomavirus (HPV)-positive...

gynecologic cancer
colorectal cancer
head and neck cancer
kidney cancer
lung cancer
issues in oncology
bladder cancer
issues in oncology

14 Million Major Medical Conditions Attributable to Cigarette Smoking

At least 14 million major medical conditions among U.S. adults aged 35 years and older were attributed to cigarette smoking by a study estimating the disease burden of cigarette smoking, which, according to the study’s authors, “remains immense.” Among current and former smokers,...

head and neck cancer

FDA Grants Lenvatinib Priority Review Designation for Advanced Thyroid Cancer

The U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application for lenvatinib mesylate as a treatment for progressive radioactive iodine–refractory differentiated thyroid cancer and granted the application Priority Review status. Lenvatinib is an oral multiple...

head and neck cancer
issues in oncology

Study Finds Potential Link Between BRCA1/2 Mutations and Salivary Gland Cancer

The risk of developing cancer in a salivary gland might be higher in people with BRCA1 or BRCA2 mutations, which are associated with breast and ovarian cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital...

head and neck cancer

New Mutations Found in Anaplastic Thyroid Cancer Lead to Dramatic Response and Acquired Resistance to Everolimus

A study involving a patient with metastatic anaplastic thyroid cancer who achieved a near-complete response to everolimus (Afinitor) that lasted for 18 months, followed by progressive disease, has revealed a previously unknown mutation in the TSC2 gene and in the mTOR protein. The discovery...

head and neck cancer
gastroesophageal cancer

Study Finds Association Between Increased Esophageal COX-2 Expression and Barrett’s Esophagus, Obesity, and Smoking

Elevated esophageal mucosa cyclooxygenase-2 (COX-2) levels appear to be associated with the presence of Barrett’s esophagus as well as high waist-to-hip ratios and current tobacco smoking, according to the results of a study reported by Nguyen et al in Digestive Diseases & Sciences. These ...

head and neck cancer

ESMO 2014: Afatinib Improves Progression-Free Survival in Advanced Head and Neck Cancer

The tyrosine kinase inhibitor afatinib (Gilotrif) was significantly superior to methotrexate as second-line therapy in patients with advanced squamous cell carcinoma of the head and neck who progressed after platinum-based chemotherapy, according to results of the LUX-Head & Neck 1 trial. The...

head and neck cancer

Pennsylvania Has High Rate of Increase in Thyroid Cancer, Including Advanced and Larger Tumors

In a population-based study reported in JAMA Otolaryngology-Head & Neck Surgery, Bann et al found that the average annual percent increase in thyroid cancer incidence in Pennsylvania approaches twice that in the rest of the country. The incidence of thyroid cancer in the United States has more...

head and neck cancer

Lymphatic Mapping Agent Receives Orphan Drug Designation for Head and Neck Cancers

Navidea Biopharmaceuticals, Inc, recently announced that technetium 99m tilmanocept (Lymphoseek Injection) has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for use in sentinel lymph node detection in patients with cancer of the head and neck. The designation...

head and neck cancer

No Benefit of Adding Cetuximab to Cisplatin and Accelerated Radiotherapy in Stage III or IV Head and Neck Carcinoma

Use of cisplatin or cetuximab (Erbitux) with radiotherapy improves overall survival in stage III or IV head and neck carcinoma, and adding cetuximab to platinum therapy improves overall survival in metastatic disease. In the phase III Radiation Therapy Oncology Group (RTOG) 0522 trial reported in...

head and neck cancer

Better Survival, but Narrowing Gap, With Surgical vs Nonsurgical Treatment of Advanced Laryngeal Cancer

Although chemoradiation has been increasingly used in advanced laryngeal cancer as part of an organ-preservation strategy, there is concern that this practice may have contributed to a decline in survival suggested by some data in this setting. In a population-based cohort study reported in JAMA...

head and neck cancer

Proposed Modification Incorporating Depth of Invasion in Primary Staging for Oral Cancer

In an analysis reported in JAMA Otolaryngology-Head & Neck Surgery, the International Consortium for Outcome Research (ICOR) in Head and Neck Cancer proposed modifying the current American Joint Committee on Cancer (AJCC) staging system for oral cancer to include depth of invasion. A model...

head and neck cancer

Taiwanese Study Shows Increased Risk of Head and Neck Cancer in Patients With Diabetes

In a Taiwanese retrospective cohort study reported in JAMA Otolaryngology–Head & Neck Surgery, Tseng et al found that diabetes was associated with increased risk of head and neck cancer, including increased risk of oral cavity, oropharyngeal, and nasopharyngeal cancers. Study Details...

head and neck cancer

Blood and Saliva Tests Help Predict Recurrence of HPV-Related Oral Cancer

Physicians at Johns Hopkins have developed blood and saliva tests that help accurately predict recurrences of HPV-linked oral cancers in a substantial number of patients. The tests screen for DNA fragments of the human papillomavirus (HPV) shed from cancer cells lingering in the mouth or other...

head and neck cancer
gastroesophageal cancer

Tumor Downstaging After Neoadjuvant Chemotherapy Strongly Predicts Improved Outcome After Surgery in Esophageal and Esophagogastric Junction Cancer

In a European analysis reported in the Journal of Clinical Oncology, Davies et al found that pathologic tumor downstaging after neoadjuvant chemotherapy was the strongest independent predictor of overall survival in patients undergoing surgery for esophageal and esophagogastric junction...

head and neck cancer
issues in oncology

Researchers Identify Genetic Mutations Linked to Salivary Gland Tumors

Research conducted at the Florida campus of The Scripps Research Institute (TSRI) has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that...

head and neck cancer

Adding Induction Chemotherapy to Chemoradiotherapy Does Not Improve Survival in Patients With N2 or N3 Locally Advanced Head and Neck Cancer

In a phase III trial reported in the Journal of Clinical Oncology, Cohen et al found that induction chemotherapy before chemoradiotherapy did not improve overall survival vs chemoradiotherapy alone in patients with N2 or N3 locally advanced squamous cell carcinoma of the head and neck. The study...

head and neck cancer

New Molecular Test Increases Odds of Correct Surgery for Thyroid Cancer Patients

The routine use of a molecular testing panel developed at the University of Pittsburgh Medical Center greatly increases the likelihood of performing the correct initial surgery for patients with thyroid nodules and cancer, reported researchers from the University of Pittsburgh Cancer Institute. The ...

head and neck cancer

Antipain Agent Shrinks Oral Cancers, Sparing Healthy Tissue

Mouse models of human oral cancer treated with an agent called capsazepine showed dramatic tumor shrinkage without damage to surrounding tissues, researchers from the School of Dentistry and School of Medicine at The University of Texas Health Science Center at San Antonio found. The findings by...

head and neck cancer
issues in oncology

Combined BRAF V600E and TERT Promoter Mutations Identify Aggressive and Recurrent Papillary Thyroid Cancer

In a study reported in Journal of Clinical Oncology, Xing et al found that the combined presence of BRAF V600E and TERT C228T mutations was associated with increased risk of recurrence and poor disease-free survival in patients with papillary thyroid cancer. The retrospective study included 365...

head and neck cancer

Meta-Analysis Indicates Better Outcomes With Charged-Particle Therapy vs Photon Therapy in Nasal Cavity and Paranasal Sinus Malignancies

Nasal cavity and paranasal sinus tumors are rare and comprise multiple histologic types, making comparative therapeutic trials difficult. In a systematic review and meta-analysis reported in The Lancet Oncology, Patel et al found that that charged-particle therapy appeared to be associated with...

head and neck cancer

Adjuvant Chemoradiation With Docetaxel Plus Cetuximab Shows Promise in High-Risk Squamous Cell Carcinoma of the Head and Neck

In the phase II Radiation Therapy Oncology Group (RTOG)-0234 trial reported in the Journal of Clinical Oncology, Harari et al found that adjuvant chemoradiation with docetaxel or cisplatin plus cetuximab (Erbitux) in patients with squamous cell carcinoma of the head and neck and high-risk...

head and neck cancer
gastroesophageal cancer

French Phase III Trial Shows No Benefit of Neoadjuvant Chemoradiation in Stage I and II Esophageal Cancer

The effect of neoadjuvant chemoradiation therapy in early-stage esophageal cancer is not clear. In the phase III FFCD 9901 trial reported in the Journal of Clinical Oncology, Mariette et al found that neoadjuvant chemoradiation including fluorouracil (5-FU) and cisplatin did not improve R0...

head and neck cancer

HPV-Positive Disease Predicts Longer Overall Survival After Progression of Oropharyngeal Squamous Cell Carcinoma

Patients with human papillomavirus (HPV)-positive oropharyngeal cancer have reduced risk of progression compared with those with HPV-negative disease, but the effect of HPV status on overall survival after progression has not been clear. In a study reported in the Journal of Clinical Oncology,...

issues in oncology
head and neck cancer

EPIC Cohort Study: High Thyroglobulin and Low TSH Precede Differentiated Thyroid Cancer, but Neither Can Be Used in Screening

In a study of the association of thyroid-stimulating hormone (TSH), thyroglobulin, and thyroid hormones with risk of differentiated thyroid cancer reported in Journal of the National Cancer Institute, Rinaldi et al found that high thyroglobulin levels can precede thyroid cancer by many years and...

head and neck cancer

Stage Migration and Dilution of Higher Stages With PET in Head and Neck Cancer in a Managed Care Setting

A study reported in JAMA Otolaryngology-Head & Neck Surgery by VanderWalde and colleagues suggests that increasing use of positron emission tomography (PET) for diagnosis and staging of head and neck cancer has resulted in considerable stage migration characterized by dilution of higher stages...

head and neck cancer

FDA Approves Radioactive Diagnostic Imaging Agent to Help Determine the Extent of Head and Neck Cancer in the Body

The U.S. Food and Drug Administration today approved a new use for technetium 99m tilmanocept (Lymphoseek Injection), a radioactive diagnostic imaging agent used to help doctors determine the extent to which squamous cell carcinoma has spread in the body’s head and neck region. In 2013,...

head and neck cancer

ASCO 2014: Lower-Dose Radiation May Reduce Long-Term Side Effects Without Compromising Survival in Certain HPV-Positive Head and Neck Cancers

According to a phase II study, customizing radiation doses based on response to induction chemotherapy and other prognostic factors may allow lower doses of radiation therapy to be administered to some patients with human papillomavirus (HPV)-positive oropharyngeal cancer without compromising...

head and neck cancer

ASCO 2014: Lenvatinib Yields High Response Rates, Delays Progression in Patients With Radioiodine-Resistant Differentiated Thyroid Cancer

A phase III, multicenter, double-blind, placebo-controlled study found that the oral targeted drug lenvatinib is highly effective among patients with differentiated thyroid cancer resistant to standard radioiodine therapy. “The main result is an extraordinary improvement in progression-free...

head and neck cancer

Physicians and Patients/Caregivers Frequently Disagree on Medicare Resource Allocations for Patients With Advanced Head and Neck Cancer

In a study reported in JAMA Otolaryngology–Head & Neck Surgery, Rocke et al compared hypothetical resource allocation by otolaryngology–head and neck surgery physicians and patients with that by advanced cancer patients or their caregivers. They found significant differences in...

head and neck cancer

No Apparent Increase in Risk of Oral HPV Infection in Sexual Partners of HPV-Positive Patients With Oropharyngeal Cancer

In a study reported in the Journal of Clinical Oncology, D’Souza et al found that while human papillomavirus (HPV)-positive patients with oropharyngeal cancer had high prevelances of oncogenic oral HPV DNA and oral HPV16 DNA, their sexual partners did not appear to have increased risk of...

head and neck cancer

Increased Incidence of Thyroid Cancer: An Epidemic of Diagnosis?

In a study reported in JAMA Otolaryngology Head & Neck Surgery, Davies and Gilbert found that the incidence of thyroid cancer has nearly tripled since 1975. However, the increase appears to represent an “epidemic of diagnosis” and to almost exclusively represent increased diagnosis...

head and neck cancer

Hyperfractionated Radiation Therapy Improves Local-Regional Control Without Increasing Late Toxicity in Locally Advanced Head and Neck Cancer

Patients with locally advanced squamous cell carcinoma of the head and neck treated with hyperfractionated radiation therapy experienced improved local-regional control and, with patients censored at 5 years, improved overall survival with no increase in late toxicity, according to a study...

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