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cns cancers
head and neck cancer

Tumor-Infiltrating Lymphocytes in Glioblastoma Are Related to Specific Genomic Alterations

The role of tumor-infiltrating lymphocytes in glioblastoma has not been fully defined. In a study reported in Clinical Cancer Research, Rutledge and colleagues assessed the association between tumor-infiltrating lymphocytes and molecular alterations, histologies, and survival in glioblastoma. In...

breast cancer
head and neck cancer
kidney cancer
lung cancer

Important News Briefs: New Data Reported in Breast, Renal Cell, Head and Neck, and Lung Cancer

The 2013 European Cancer Congress (ECC), held September 27 to October 1 in Amsterdam, was jointly sponsored by the European Society of Medical Oncology, the European Cancer Organization, and the European Society of Radiation Oncology. With the Congress theme being “Reinforcing Multidisciplinarity,” ...

head and neck cancer

It Sounds Crazy, but Cancer Has Made Me a Better Chef

I was diagnosed with stage IVB squamous cell carcinoma of the tongue in 2007, when I was just 33 years old, but the cancer had started to show itself long before then. I first noticed a white dot on the left side of my tongue in 2002, and as time went on, the sore became annoying and hurt when it...

head and neck cancer

Novel EGFR Inhibitor Added to Radiotherapy Fails to Improve Outcomes in Head and Neck Cancer

The addition of zalutumumab, an investigational epidermal growth factor receptor (EGFR) inhibitor, to primary chemoradiotherapy did not increase locoregional control or improve survival at 3 years in patients with squamous cell carcinoma of the head and neck compared with chemoradiotherapy alone,...

head and neck cancer

Spanning a Spectrum of Issues Related to Head and Neck Cancers

Five recent articles in JAMA Otolaryngology–Head & Neck Surgery1-5 span a spectrum of issues related to head and neck cancers. These include risk factors, concentration of care to teaching hospitals, avoiding venous thromboembolism, and encouraging patients to eat and do swallowing exercises to ...

head and neck cancer

FDA Approves Radioactive Diagnostic Imaging Agent to Help Determine the Extent of Head and Neck Cancer in the Body

The U.S. Food and Drug Administration has approved a new use for technetium 99m tilmanocept (Lymphoseek Injection), a radioactive diagnostic imaging agent used to help doctors determine the extent to which squamous cell carcinoma has spread in the body’s head and neck region. In 2013, tilmanocept...

head and neck cancer
issues in oncology

Limited Public Awareness of Head and Neck Cancers Raises Concerns About Prevention and Detection

Public awareness of head and neck cancer is limited, with the lack of awareness including the term head and neck cancer and common symptoms and risk factors, such as tobacco use and human papillomavirus (HPV), according to results of a cross-sectional online survey reported in JAMA...

head and neck cancer

Head and Neck Societies Proclaim July 27th 'World Head and Neck Cancer Day'

The International Federation of Head and Neck Oncologic Societies ­(IFHNOS), as part of the opening ceremonies of its 5th World Congress, and in collaboration with the annual meeting of the American Head and Neck Society (AHNS), will proclaim July 27th as “World Head and Neck Cancer Day.”   The...

head and neck cancer

Identifying and Managing Distress in Patients With Head and Neck Cancers

A quality improvement initiative at the Norris Cotton Cancer Center in Lebanon, New Hampshire, resulted in biweekly screening rates for psychological distress among patients treated at the head and neck medical oncology clinic increasing from 0% to 74% within a 2-year period. “Distress screening...

head and neck cancer
supportive care

Mucositis Remains a Challenge in Head and Neck Cancer

Chemoradiotherapy for head and neck cancer requires intensive supportive care by a knowledgeable and proactive multidisciplinary team, according to Avraham Eisbruch, MD, Professor of Radiation Oncology at the University of Michigan, Ann Arbor. “Aggressive chemoradiotherapy has improved the cure...

head and neck cancer

TP53 Mutation Associated With Chromosome 3p Loss in Head and Neck Squamous Cell Carcinoma

In an analysis of molecular and clinical features associated with survival in head and neck squamous cell carcinoma reported in Nature Genetics, Gross and colleagues found that the TP53 mutation is frequently accompanied by loss of chromosome 3p; the combination of these alterations was associated...

head and neck cancer

Lymphatic Mapping Agent Receives Orphan Drug Designation for Head and Neck Cancers

Navidea Biopharmaceuticals, Inc, recently announced that technetium 99m tilmanocept (Lymphoseek Injection) has been granted Orphan Drug Designation by the U.S. Food & Drug Administration (FDA) for use in sentinel lymph node detection in patients with cancer of the head and neck. The designation ...

head and neck cancer

Adding Cetuximab to Chemoradiation Did Not Benefit Patients With Advanced Head and Neck Cancer: What Were the Reasons?

Two landmark randomized studies demonstrated improved survival of patients with head and neck cancer receiving the epidermal growth factor receptor (EGFR) antibody cetuximab (Erbitux) concurrent with radiotherapy compared with radiotherapy alone,1 and similar improvement in patients with...

head and neck cancer

No Benefit Seen for Cetuximab Added to Cisplatin and Accelerated Radiotherapy in Advanced Head and Neck Carcinoma

Use of cisplatin or cetuximab (Erbitux) with radiotherapy improves overall survival in stage III or IV head and neck carcinoma, and adding cetuximab to platinum therapy improves overall survival in metastatic disease. In the phase III Radiation Therapy Oncology Group (RTOG) 0522 trial reported in...

head and neck cancer

Old Woman With Eye Tumor, circa 1878

This is a rare photograph of an older patient with a primary ocular tumor. These tumors are uncommon in old age so most photographs of retinoblastoma or rhabdomyosarcoma featured children. As a rule, there was no attempt to surgically remove these tumors and the children were only given supportive...

head and neck cancer

Radiation Treatment for Facial Cancer, Boston, 1903

Diseases and cancers of the face were so visible and disfiguring that they were usually brought to the attention of a physician in their early stages. The effect and success produced by Finsen’s light therapy on lupus, eczema, psoriasis, other skin diseases and even infections, such as...

head and neck cancer
issues in oncology

mTOR Cotargeting Active in Cetuximab-Resistant Head/Neck Cancers With PIK3CA and RAS Mutations

In a study reported in Journal of the National Cancer Institute, Wang and colleagues found that adding an mTOR inhibitor to cetuximab (Erbitux) resulted in marked improvement in antitumor activity in squamous cell carcinomas of the head and neck expressing PIK3CA and RAS oncogenes. Cetuximab...

head and neck cancer

Intraperitoneal Oxidative Stress Induces Tumoricidal Immune Response in Papillomavirus-Linked Head/Neck Cancer

In a study reported in Clinical Cancer Research, Rossmann and colleagues found that induction of oxidative stress via O3/O2 pneumoperitoneum treatment in the papillomavirus-associated rabbit auricular VX2 carcinoma model of head and neck cancer resulted in a tumoricidal immune response that could...

head and neck cancer

Functional Kinomics Identifies WEE1 Kinase as Target in Head and Neck Cancer

In a study reported in Clinical Cancer Research, Moser and colleagues used RNA interference kinase viability screens to identify survival kinases (involved in G2-M cell-cycle checkpoint, SFK, PI3K, and FAK pathways) in p53-mutant head and neck squamous cell carcinoma. Selected kinase targets were...

head and neck cancer

Antacids Linked to Better Survival in Patients With Head and Neck Cancer

Patients with head and neck cancer who used antacid medicines to control acid reflux had better overall survival, according to a study from the University of Michigan Comprehensive Cancer Center. Results of the study were published in Cancer Prevention Research.1 Reflux can be a common side effect ...

head and neck cancer
lung cancer

Coupling Head and Neck Cancer Screening and Lung Cancer Scans Could Improve Early Detection, Survival

Adding head and neck cancer screenings to recommended lung cancer screenings would likely improve early detection and survival, according to a multidisciplinary team led by scientists affiliated with the University of Pittsburgh Cancer Institute (UPCI), a partner with the University of Pittsburgh...

head and neck cancer

Treating Head and Neck Cancer in 2015

Each year in the United States, about 55,000 people will be diagnosed with head and neck cancer, and of them, about 12,000 will die of the disease. Although advances have been made in the treatment of head and neck cancer, this disease remains persistently problematic, due, in part, to the complex...

head and neck cancer

The Center of Who We Are

The following essay by Eric M. Genden, MD, is adapted from The Big Casino: America’s Best Cancer Doctors Share Their Most Powerful Stories, which was coedited by Stan Winokur, MD, and Vincent Coppola and published in May 2014. The book is available on Amazon.com and thebigcasino.org.   There’s...

head and neck cancer

ESMO Asia 2015: Immunotherapy and Targeted Therapy Provide New Options for Difficult-to-Treat Head and Neck Cancer

Novel strategies are being explored for difficult-to-treat and advanced head and neck cancer—the most heterogeneous group of malignancies that are generally associated with poor survival—and encouraging results have been presented in two trials at the first European Society for Medical...

head and neck cancer
issues in oncology

Patients With Thyroid Cancer Report Poor Quality of Life Despite ‘Good’ Diagnosis

Thyroid cancer survivors report poor quality of life after diagnosis and treatment compared with other patients who are diagnosed with more lethal cancers, according to new research from the University of Chicago Medicine. The findings, published by Aschebrook-Kilfoy et al in the journal Thyroid,...

head and neck cancer
survivorship

Depressed Head and Neck Cancer Patients 3.5 Times Less Likely to Survive, Have Higher Recurrence Risk

Depression is a significant predictor of 5-year survival and recurrence in head and neck cancer patients, according to a new study from The University of Texas MD Anderson Cancer Center. These findings, published by Shinn et al in Psychosomatic Medicine, represent one of the largest reported...

kidney cancer
lung cancer
skin cancer
lymphoma
kidney cancer
head and neck cancer

Kidney Failure and Its Treatment May Impact Cancer Risk

For patients with kidney failure, poor kidney function and immunosuppressant medications may increase their risk of developing different types of cancer. The findings, which are published by Yanik et al in the Journal of the American Society of Nephrology, suggest the need for persistent cancer...

head and neck cancer
issues in oncology

Researchers Discover SEC23B, Gene Associated With Cowden Syndrome, Contributes to Thyroid Cancer Risk

Cleveland Clinic researchers have discovered a gene associated with Cowden syndrome, an inherited condition that carries high risks of thyroid, breast, and other cancers, and a subset of noninherited thyroid cancers. These findings were published by Yehia et al in the American Journal of Human...

head and neck cancer
supportive care

ASTRO 2015: Frequent Post-Treatment Follow-up by Advance Practice Nurses Improves Care for Patients With High-Risk Head and Neck Cancer

For high-risk patients who receive chemoradiotherapy for head and neck cancer, frequent follow-up appointments conducted by advance practice nurses (APNs) in a clinical outpatient setting allowed for more intensive symptom management, resulting in fewer post-treatment emergency room visits and...

head and neck cancer
issues in oncology

ASTRO 2015: Reduced-Intensity Chemoradiotherapy May Be as Effective as Current Standard for Patients With HPV-Related Oropharynx Cancer

For some patients with human papillomavirus (HPV)-related cancer of the tonsils and tongue, reduced-intensity radiation therapy and chemotherapy may be as effective as standard-dose radiation and chemotherapy, and result in fewer acute side effects, according to research presented by Chera et al...

head and neck cancer
issues in oncology

Disparities in Outcomes for Children With Retinoblastoma May Suggest Unequal Access to Primary Care

Disparities in outcomes for children with retinoblastoma suggest unequal access to primary care, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center reported in a study published by Truong et al in JAMA Pediatrics. Although virtually all the children in the study...

head and neck cancer

ECC 2015: Pembrolizumab in Patients With Advanced Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Trial

Pembrolizumab (Keytruda), an anti–PD-1 therapy, may be effective as monotherapy in patients with advanced unresectable nasopharyngeal carcinoma whose tumors express programmed cell death-ligand 1 (PD-L1). Data from a phase Ib study, KEYNOTE-028, showed an overall response rate of 22.2% in 27...

head and neck cancer
survivorship

ECC 2015: Association Between Primary Surgery and Survival Benefit in Patients With Advanced Throat Cancers

Patients with cancers of the mid and lower throat may have higher survival rates if their initial treatment includes surgery, according to new research (Abstract 2804) presented at the 2015 European Cancer Congress in Vienna, Austria. Researchers explained that a nationwide study in Taiwan found...

issues in oncology
head and neck cancer

Researchers Discover Novel Marker for Retinoblastoma

A new marker already linked to other types of cancer was found to play a role in the most common childhood primary tumor inside the eye, researchers at the University of Michigan Health System have found. Their findings were published by Khan et al in Laboratory Investigation. Retinoblastoma is a...

head and neck cancer

Persistent HPV16 DNA in Post-Treatment Oral Rinse Associated With Poor Prognosis in HPV-Related Oropharyngeal Carcinoma

In a prospective cohort study reported in JAMA Oncology, Rettig et al found that persistent human papillomavirus (HPV) type 16 DNA in post-treatment oral rinses was associated with a poorer prognosis in patients with HPV-related oropharyngeal cancer. The study included 124 patients treated with...

head and neck cancer
issues in oncology

Susceptibility Gene Identified for Familial Nonmedullary Thyroid Cancer

As reported in The New England Journal of Medicine, Gara et al identified a germline HABP2 mutation as a susceptibility gene for familial nonmedullary thyroid cancer. Identification of HABP2 Variant In a kindred study, whole-exome sequencing was performed using peripheral blood DNA from affected...

issues in oncology
head and neck cancer
issues in oncology

Researchers Decode Molecular Action of Combination Therapy for Anaplastic Thyroid Cancer

In their bid to find the best combination of therapies to treat anaplastic thyroid cancer, researchers at Mayo Clinic's Florida campus demonstrated that all histone deacetylase (HDAC) inhibitors are not created equal. In testing multiple HDAC inhibitors in combination with the chemotherapy drug...

head and neck cancer
issues in oncology

30-Year Study Shows Moderate Hormone Suppression May Be Sufficient in Thyroid Cancer

A study of long-term thyroid cancer outcomes shows, among other findings, that moderate suppression of thyroid-stimulating hormone, which drives the disease, may be as beneficial as more extreme hormone suppression. Extreme thyroid-stimulating hormone suppression is associated with increased side...

head and neck cancer

Two-Thirds of Patients With Locally Advanced Laryngeal Cancer Not Receiving Recommended Treatment

Despite findings of previous studies and published guidelines, nearly two-thirds of patients with T4a laryngeal cancer are not receiving a total laryngectomy—the recommended form of treatment—and, as a result, have significantly worse survival rates vs those treated with a total...

issues in oncology
head and neck cancer
issues in oncology
issues in oncology

DNA Shed From Head and Neck Tumors Detected in Blood and Saliva

On the hunt for better cancer screening tests, Johns Hopkins scientists led a proof-of-principle study that successfully identified tumor DNA shed in the blood and saliva of 93 patients with head and neck cancer. A report on the findings was published by Wang et al in Science Translational...

palliative care
colorectal cancer
head and neck cancer

Development of New Blood Vessels Not Essential to Growth of Lymph Node Metastases

While the use of antiangiogenesis drugs that block the growth of new blood vessels can improve the treatment of some cancers, clinical trials of their ability to prevent the development of new metastases have failed. Now a study from the Massachusetts General Hospital (MGH) Cancer Center may have...

issues in oncology
breast cancer
head and neck cancer
gynecologic cancer
issues in oncology
bladder cancer
issues in oncology

Immune Signaling Protein May Have Opposing Roles in Breast Cancer Development

Researchers at The University of Texas MD Anderson Cancer Center have discovered that inhibiting the immune receptor protein TLR4 may not be a wise treatment strategy in all cancers, as research now shows TLR4 can either promote or inhibit breast cancer cell growth depending on mutations in...

issues in oncology
head and neck cancer

Lymph Nodes Signal More Aggressive Thyroid Cancer, Even in Young Patients

Patients older than age 45 with thyroid cancer that has spread to neck lymph nodes have long been considered at higher risk of dying, but the same has not been true for younger patients. Now researchers at the Duke Cancer Institute and the Duke Clinical Research Institute have found that...

issues in oncology
head and neck cancer
issues in oncology

HPV Serum Antibodies May Predict Survival and Disease Progression in Patients With HPV-Positive Oropharyngeal Cancer

A study by Dahlstrom et al investigating the usefulness of serum antibodies to human papillomavirus (HPV)-16 DNA antigens as predictors of survival for patients with oropharyngeal carcinoma has found that E1, NE2, and E6 antibody positivity were all strongly associated with improved overall and...

head and neck cancer

ASCO 2015: Elective Neck Dissection Improves Early Oral Cancer Survival

A randomized phase III study resolves long-standing questions about the optimal timing of neck lymph node surgery for patients with early-stage oral cancer by showing that elective neck dissection both improves survival and lowers recurrence rates compared to therapeutic neck dissection performed...

head and neck cancer

ASCO 2015: Pembrolizumab Produces Clinically Meaningful Response in Patients With Recurrent or Metastatic Head and Neck Cancer

Immunotherapy with pembrolizumab (Keytruda) produced a clinically meaningful overall response rate in a study among 132 patients with recurrent or metastatic squamous cell carcinoma of the head and neck. The overall objective response rate was 24.8%, and 57% of patients experienced some tumor...

head and neck cancer

Updated Meta-Analysis Confirms Survival Benefit of Adding Chemotherapy to Radiotherapy in Nasopharyngeal Cancer

In an updated patient-level meta-analysis reported in The Lancet Oncology, Blanchard et al of the Meta-Analysis of Chemotherapy in Nasopharyngeal Carcinoma (MAC-NPC) collaborative group found that the addition of chemotherapy to radiotherapy improved overall survival in patients with nasopharyngeal ...

gynecologic cancer
solid tumors
gynecologic cancer
head and neck cancer
issues in oncology

Nine-Valent HPV Vaccine Protects Against 80% of Cervical Cancers

The new nine-valent human papillomavirus (HPV) vaccine (Gardasil 9) can potentially prevent 80% of cervical cancers in the United States, if given to all 11- or 12-year-old children before they are exposed to the virus. Additionally, the new vaccine, which includes seven cancer-causing...

head and neck cancer

Afatinib Improves Progression-Free Survival vs Methotrexate in Platinum-Treated Recurrent or Metastatic Head and Neck Cancer

In the phase III LUX-Head & Neck 1 trial reported in The Lancet Oncology, Machiels et al found that afatinib (Gilotrif) improved progression-free survival vs methotrexate in patients with recurrent or metastatic squamous cell carcinoma of the head and neck progressing after first-line platinum...

gynecologic cancer
head and neck cancer
issues in oncology

AACR 2015: HPV Vaccine Provides Protection at Multiple Sites, Even Among Some Previously Exposed Patients

Vaccination of women aged 18 to 25 with the human papillomavirus (HPV) vaccine resulted in strong protection against future infection at three anatomic sites among women without prior HPV exposure and may still offer some protection in those with evidence of prior exposure. These findings were...

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