Your search for cns cancers matches 225 pages

Showing 101 - 150


cns cancers

Whole-Brain Radiation Therapy Plus Stereotactic Radiosurgery Improves Survival in Better-Prognosis Patients With Brain Metastases

In a secondary analysis utilizing the graded prognostic assessment—an improved diagnosis-specific index—patients with one to three brain metastases had no survival advantage when treated with whole-brain radiation therapy and stereotactic radiosurgery, compared with whole-brain radiotherapy alone,...

cns cancers

Ten Best-Practice Measures Improve Quality of Care During Perioperative Period for Patients With Glioma

Ten best-practice measures identified by a multidisciplinary team at the Norris Cotton Cancer Center (NCCC) at the Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire, were used to improve the care provided to patients with glioma during the perioperative period. “Using a plan-do-study-act ...

cns cancers

Clinical Trials Actively Recruiting Patients With Glioblastoma

The information contained in this Clinical Trials Resource Guide includes actively recruiting clinical studies for patients with newly diagnosed or recurrent glioblastoma multiforme. The studies include pilot, phase I, I/II, III, and observational trials investigating chemoradiation therapy;...

cns cancers

Dr. Howard Fine Named Founding Director of the Brain Tumor Center at NewYork-Presbyterian Hospital/Weill Cornell Medical Center

Howard A. Fine, MD, has been appointed to lead the newly established neuro-oncology program at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, effective February 2. He will serve as Director of the Brain Tumor Center and Associate Director for Translational Research in the Sandra and...

cns cancers

Glioblastoma Clinical Trials

I am writing in regard to the recent installment to “Clinical Trials” on Glioblastoma published in The ASCO Post (February 10, 2015, pages 69-71). As a principal investigator, I’d also like to call attention to the following glioblastoma trial, which remains open.   PHASE II Study Type:...

cns cancers

Having Cancer So Early in Life Gave Me Purpose

I had every classic brain tumor symptom in the book—severe headaches, dizziness, morning nausea—which plagued me for 16 years, starting when I was 8. In college, if I allowed myself to sleep more than 4 hours a night, the morning headaches, which were centered on the top of my head, were so severe, ...

cns cancers

Dinutuximab Combination Approved for Pediatric High-Risk Neuroblastoma

The U.S. Food and Drug Administration (FDA) has approved dinutuximab (Unituxin), a monoclonal antibody targeting glycolipid GD2,  as part of first-line therapy for pediatric patients with high-risk neuroblastoma. A chimeric monoclonal antibody that binds to the surface of neuroblastoma cells,...

cns cancers

Dinutuximab in Pediatric High-Risk Neuroblastoma

In the Clinic provides overviews of novel oncology agents, addressing indications, mechanisms, administration recommendations, safety profiles, and other essential information needed for the appropriate clinical use of these drugs.   On March 10, 2015, the chimeric monoclonal antibody dinutuximab ...

cns cancers

Clinical Trials Actively Recruiting Patients With Neuroblastoma

The information contained in this Clinical Trials Resource Guide includes actively recruiting clinical studies for patients with newly diagnosed or relapsed or refractory neuroblastoma. The studies include pilot, observational, phase I, phase II, and phase III trials investigating single-agent and...

cns cancers

Will the PVS-RIPO Poliovirus Be a Game Changer in the Treatment of Recurrent Glioblastoma?

Although the idea of using viruses to target cancer cells dates back more than 100 years, technologic advances in the genetic engineering of viruses are now making it possible to safely test oncolytic virotherapy as a valid strategy against cancer cells. One type of genetically engineered virus...

cns cancers

New Concept for Brain Tumors: Tumor Treating Fields

A novel treatment modality that applies electric forces to brain tumors via scalp electrodes improved outcomes in a study reported at the 2015 ASCO Annual Meeting.1 In the first report of the full dataset, tumor treating fields significantly and consistently prolonged both progression-free...

issues in oncology
cns cancers

DNA Repair Enzyme Identified as a Potential Brain Cancer Drug Target

Rapidly dividing cells rely on an enzyme called Dicer to help them repair the DNA damage that occurs as they make mistakes in copying their genetic material over and over for new cells. Researchers have built on the discovery of Dicer’s role in fixing DNA damage to uncover a new potential...

cns cancers

Prognostic Factors in Men With Brain Metastases From Germ Cell Tumors

As reported in the Journal of Clinical Oncology, Feldman et al, of the Global Germ Cell Cancer Group, identified prognostic factors in men with brain metastases from germ cell cancer at initial diagnosis or relapse. Overall survival was better in patients with metastases at diagnosis, a greater...

lung cancer
cns cancers

Prognostic Factors Identified in Patients With ALK‑Rearranged NSCLC and Brain Metastasis

In a study reported in the Journal of Clinical Oncology, Johung and colleagues identified factors that distinguished survival rates among patients with ALK-rearranged non–small cell lung cancer (NSCLC) and brain metastasis. The study included 90 patients from six institutions. Of them, 84...

cns cancers

Experimental Drug Shown to Prevent Neuroblastoma in Preclinical Study

Australian scientists have identified a critical molecular “feedback loop” that helps initiate and drive neuroblastoma, a cancer of the nervous system in children that is triggered in embryonal nerve cells. This feedback loop massively accelerates cancer development. The research team...

cns cancers

Preclinical Study Finds Pediatric Low-Grade Gliomas With CRAF Fusions May Require Differential and Combinatorial Targeted Therapies

Pediatric low-grade gliomas are the most common type of brain tumor diagnosed in children, and represent a heterogeneous group of tumors, which are poorly classified based on histology and location, according to Payal Jain, a graduate student at the University of Pennsylvania, and lead author of a...

cns cancers
survivorship

Chemotherapy-Induced Hearing Loss Affects Cognition in Pediatric Brain Tumor Survivors

More children are surviving malignant brain tumors than in the past, thanks to the use of intense treatments using platinum-based chemotherapy (cisplatin and high-dose carboplatin). Unfortunately, the therapy has a known side effect of permanent hearing loss, resulting from damage to the inner ear. ...

cns cancers
supportive care

Telotristat Etiprate Shows Clinical Benefit in Treating Carcinoid Syndrome in Cancer Patients When Added to Standard of Care

Lexicon Pharmaceuticals, Inc's telotristat etiprate was shown to have clinical benefit in treating carcinoid syndrome in cancer patients not adequately controlled by long-acting somatostatin analog therapy, the current standard of care, according to data from the phase III TELESTAR study presented...

cns cancers
cns cancers

ASTRO 2015: Pediatric Patients With Ependymoma Have Favorable Outcomes With Immediate Postsurgical Radiation Therapy

Outcomes for pediatric patients as young as 12 months old with ependymoma who are treated with immediate postoperative radiation therapy are favorable and consistent, based upon tumor surgical resection and tumor grade, according to research presented by Merchant et al (Abstract 1) on October...

cns cancers

ASTRO 2015: Patients With Intermediate-Risk Meningiomas Who Receive Postoperative Radiotherapy Have a 96% 3-Year Progression-Free Survival

Patients with intermediate meningiomas treated with radiation therapy after surgery experienced a 96% 3-year progression-free survival rate and had minimal adverse events, according to research presented by Rogers et al October 21, 2015, at the American Society for Radiation Oncology’s...

cns cancers

Targeted Chemotherapy Shows Early Signs of Slowing Neuroblastoma Tumor Growth With Less Toxicity in Preclinical Models

Surviving neuroblastoma as a child can come with just as many challenges as the cancer itself, mainly because of the toxic effects of chemotherapy. But a team of surgeons is in the nascent stages of developing a more targeted, less toxic method of treating neuroblastoma patients with chemotherapy....

cns cancers

No Difference in Outcomes With Short-Course vs Longer-Course Radiotherapy in Elderly or Frail Patients With Newly Diagnosed Glioblastoma

In a noninferiority phase III trial reported in the Journal of Clinical Oncology, Roa et al found no difference in overall survival, progression-free survival, or quality of life between short-course and longer-course radiotherapy in elderly or frail patients with newly diagnosed glioblastoma...

cns cancers

FDA Approves Expanded Indication for Medical Device to Treat Newly Diagnosed Glioblastoma Multiforme

The U.S. Food and Drug Administration (FDA) today approved an expanded indication for the Optune tumor treating fields device to treat patients with newly diagnosed glioblastoma multiforme. It is given along with the chemotherapy drug temozolomide following standard treatments that include...

solid tumors
lung cancer
cns cancers

ECC 2015: Lung and Gastrointestinal Neuroendocrine Tumors and Results From the RADIANT-4 Trial

An international team of researchers has shown that the use of the mTOR inhibitor everolimus can delay tumor growth among both gastrointestinal and lung neuroendocrine tumors. This is particularly important for patients with lung tumors, the researchers say, because there is currently no approved...

solid tumors
cns cancers

ECC 2015: Advanced Gastrointestinal Neuroendocrine Tumors and Results From the NETTER-1 Trial

Results from a multicenter randomized international trial of an innovative treatment show a marked improvement in the length of time patients with midgut neuroendocrine tumors experience progression-free survival, researchers reported at the 2015 European Cancer Congressin Vienna, Austria, on...

cns cancers
issues in oncology

ECC 2015: Genetic Screening of Brain Metastases Could Reveal New Targets for Treatment

Unraveling the genetic sequences of cancer that has spread to the brain could offer unexpected targets for effective treatment, according to new research (Abstract 2905) presented at the 2015 European Cancer Congress in Vienna, Austria, and published simultaneously by Brastianos et al in...

cns cancers

Long-Term Infusion of Immunotherapy May Reduce Pain in Children With High-Risk Neuroblastoma

Changing the infusion delivery method of the monoclonal antibody ch14.18/CHO (dinutuximab-beta, the European counterpart of dinutuximab [Unituxin]) in combination with interleukin-2 and oral 13-cis-retinoic acid from short-term infusion to long-term infusion in the treatment of children with...

cns cancers

Combination of Chemotherapy and T-Cell Immunotherapy May Provide Novel Treatment Strategy for Glioblastoma

A preclinical study has found that a combination of decitabine and T-cell immunotherapy demonstrated antitumor activity against glioblastomas in mouse models and was about 50% effective at curing the disease. The results, reported by Everson et al in Neuro-Oncology, show an innovative,...

cns cancers

Complete Resection of High-Grade Gliomas Yields Better Survival in Children, Especially Girls

For children with aggressive brain cancers called high-grade gliomas, the chances of survival are improved when surgery is successful in eliminating all visible cancer, according to a report published by McCrea et al in Neurosurgery. In addition to showing better survival with gross total...

cns cancers

Study Reveals Effects of Chemoradiation in Brains of Glioblastoma Patients

A study from Massachusetts General Hospital (MGH) Cancer Center researchers—the first to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients—revealed not only specific structural changes within patients’ brains, but also...

cns cancers
issues in oncology

Medullablastomas Can Be Classified Noninvasively at Diagnosis

Medulloblastoma, the most commonly occurring malignant brain tumor in children, can be classified into four subgroups, each with a different risk profile requiring subgroup-specific therapy. Currently, subgroup determination is done after surgical removal of the tumor. Investigators at...

cns cancers
gynecologic cancer
colorectal cancer
leukemia
lymphoma
skin cancer
gynecologic cancer
issues in oncology
issues in oncology
issues in oncology

Noninvasive Prenatal Testing May Also Detect Some Maternal Cancers

A study published by Bianchi et al in the Journal of the American Medical Association (JAMA) showed that genetic test results revealed by noninvasive prenatal testing for fetal chromosomal abnormalities may detect underlying conditions in the mother, including cancer. The study reports on a case...

cns cancers

FDA Grants Orphan Drug Designation to Anti‑Tropomyosin Drug for Neuroblastoma

The U.S. Food and Drug Administration (FDA) has granted Orphan Drug designation to Novogen Limited’s chemotherapy candidate drug Anisina for neuroblastoma. Anisina is a small molecule belonging to a family of compounds called anti-tropomyosins. It has been designed to inhibit Tpm3.1, a...

issues in oncology
cns cancers

Early Study Suggests Which Glioblastoma Patients May Benefit From Dasatinib

Clinicians testing the drug dasatinib (Sprycel), approved for several blood cancers, had hoped it would slow the aggressive growth of the deadly brain cancer glioblastoma; however, clinical trials to date have not found any benefit. Researchers at Mayo Clinic, who conducted one of those clinical...

cns cancers
issues in oncology

Molecular Classification of Glioma Based on IDH Mutation, 1p/19q Codeletion, and TERT Promoter Mutation Status

In a study reported in The New England Journal of Medicine, Eckel-Passow et al identified a molecular classification scheme for gliomas based on IDH mutation, codeletion of chromosome arms 1p and 19q (1p/19q codeletion), and TERT promoter mutation status. Molecular Classification The study...

palliative care
cns cancers
issues in oncology
issues in oncology

ASCO 2015: Gene Therapy Paired With Traditional Surgical Resection Benefits Patients With Glioblastoma

Houston Methodist Neurological Institute neurosurgeon David Baskin, MD, presented preliminary data from a phase II clinical trial that suggests gene therapy  (AdV-Tk therapy), which uses a mediated herpes simplex virus, combined with a traditional treatment—surgical resection—could ...

cns cancers
issues in oncology

Assay Permits Rapid Molecular Characterization of Glioma

As reported in JAMA Oncology, Shankar et al developed a rapid genotyping assay to detect single nucleotide variants in telomerase reverse transcriptase (TERT) promoter and isocitrate dehydrogenase 1 (IDH1) genes that may assist in intraoperative decisions to perform definitive neurosurgical...

issues in oncology
cns cancers
issues in oncology

Multicenter Study Redefines Brain Tumor Diagnosis and Treatment 


Scientists at multiple institutions have found a new way of classifying brain cancers that could very well change how the illness is diagnosed and treated. The study, a project of The Cancer Genome Atlas, found striking molecular differences between various forms of gliomas by looking at the makeup ...

cns cancers

ASCO 2015: Glioblastoma Poliovirus Therapy Works Best at a Low Dosage

A modified poliovirus therapy that is showing activity in patients with glioblastoma works best at a low dosage, according to the research team at Duke’s Preston Robert Tisch Brain Tumor Center. The dosage findings for the first 20 patients in the phase 1 trial were presented June 1 at the...

cns cancers
issues in oncology

ASCO 2015: Study Supports IDH Gene as Prognostic Marker in Anaplastic Astrocytoma

New findings from a phase III clinical trial suggest the IDH1 gene may be a prognostic marker for anaplastic astrocytoma, a rare form of brain cancer. The results of this study were presented on June 2 at the 2015 ASCO Annual Meeting in Chicago (Abstract 2002). Patients in this study who had a...

cns cancers
issues in oncology

Addition of Bevacizumab to Radiotherapy and Temozolomide Does Not Worsen Health-Related Quality of Life in Glioblastoma Patients

In the phase III AVAglio trial, the addition of bevacizumab (Avastin) to radiotherapy and temozolomide improved progression-free survival in patients with newly diagnosed glioblastoma. As reported by Taphoorn et al in the Journal of Clinical Oncology, bevacizumab treatment did not worsen...

cns cancers
issues in oncology

Blood Thinners Safe for Cancer Patients With Brain Metastases

Cancer patients with brain metastases who develop blood clots may safely receive blood thinners without increased risk of dangerous bleeding, according to a study published by Donato et al in Blood. Cancer increases a patient’s risk of developing blood clots, and an anticoagulant is often...

cns cancers
issues in oncology

Preclinical Study Points to Possible Treatment for Lethal Pediatric Brain Cancer

Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat (Farydak) and similar gene-regulating drugs may be effective at treating diffuse intrinsic pontine glioma (DIPG), an aggressive and lethal form of...

cns cancers
supportive care

Donepezil Provides Modest Improvement in Cognitive Function Domains in Irradiated Brain Tumor Survivors

In a phase III trial reported in the Journal of Clinical Oncology, Rapp et al found that the neurotransmitter modulator donepezil may modestly improve some cognitive function domains in patients undergoing cranial irradiation for brain tumors. Improvements were greater in patients with greater...

cns cancers
issues in oncology
supportive care
issues in oncology

Study Recommends Brain Cancer Patients Be Screened for Depression

Depression in brain cancer patients is a common but often overlooked condition, and oncologists should regularly screen tumor patients for depression, according to an article by Pranckeviciene and Bunevicius in CNS Oncology. The authors, both of the Lithuanian University of Health Sciences,...

cns cancers
issues in oncology

Preliminary Study Reveals Gene Regulatory Path as Target for Aggressive Pediatric Brain Cancer

Working with cells taken from children with a very rare but aggressive form of brain cancer, Johns Hopkins Kimmel Cancer Center scientists have identified a genetic pathway that acts as a master regulator of thousands of genes, and may spur cancer cell growth and resistance to anticancer treatment. ...

cns cancers

NIH-Funded Study Suggests Novel Strategy to Improve Vaccine Efficacy in the Treatment of Glioblastoma

Although dendritic cell–based immunotherapy has shown limited promise in the treatment of patients with advanced cancers, including glioblastoma, the factors dictating dendritic cell–based vaccine efficacy have been poorly understood. Now, a clinical trial funded by the National...

cns cancers

Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma Defined by BRAF Mutation and CDKN2A Deletion

In a study reported in the Journal of Clinical Oncology, Mistry et al found that presence of BRAF V600E mutation and CDKN2A deletion defined a clinically distinct subtype of pediatric secondary high-grade glioma. BRAF V600E mutation was associated with a prolonged time to transformation. Study...

cns cancers

Clinical Trial Suggests Temozolomide-Based Chemoradiation Is Best for Low-Grade Brain Tumors

New clinical trial findings provide further evidence that combining chemotherapy with radiation therapy is the best treatment for people with a low-grade form of brain cancer. The findings come from a phase II study co-led by a researcher at Ohio State University Comprehensive Cancer...

cns cancers

Similar Local Recurrence Rates But Increased Distant Metastases With Adjuvant Localized vs Whole-Brain Radiotherapy in Patients With Brain Metastases

In patients who had undergone surgery for brain metastases, the rate of recurrence at the resected site was similar between patients who received adjuvant whole-brain radiotherapy vs those who underwent adjuvant localized radiotherapy, according to a retrospective study by Hsieh et al in the...

Advertisement

Advertisement



Advertisement