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Recent Decrease in Deaths Attributable to Breast Cancer in the United States

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Key Points

  • Cumulative breast cancer deaths averted from 1990 to 2015 ranged from more than 305,000 women to more than 483,000 women, depending on different background mortality assumptions. When extrapolating results to 2018, cumulative breast cancer deaths averted since 1989 ranged from 384,000 to 614,500.
  • The investigators calculated that mammography and improved treatment decreased the expected mortality rate of breast cancer in 2018 by 45.3% to 58.3%.

The latest U.S. estimates indicate that since 1989, hundreds of thousands of women's lives have been saved by mammography and improvements in breast cancer treatment. In a study published by Hendrick et al in Cancer, findings point to progress made in the early detection and management of breast cancer.

Screening mammography for the detection of breast cancer became widely available in the mid-1980s, and various effective therapies have been developed since that time. To estimate the number of breast cancer deaths averted since 1989 due to the collective effects of both screening mammography and improved treatment, R. Edward Hendrick, PhD, of the University of Colorado School of Medicine; Jay Baker, MD, of Duke University Medical Center; and Mark Helvie, MD, of the University of Michigan Health System, analyzed breast cancer mortality data and female population data for U.S. women aged 40 to 84 years over the past 3 decades.

Analysis Findings

Cumulative breast cancer deaths averted from 1990 to 2015 ranged from more than 305,000 women to more than 483,000 women, depending on different background mortality assumptions. When extrapolating results to 2018, cumulative breast cancer deaths averted since 1989 ranged from 384,000 to 614,500. When considering 2018 alone, an estimated 27,083 to 45,726 breast cancer deaths were averted. The investigators calculated that mammography and improved treatment decreased the expected mortality rate of breast cancer in 2018 by 45.3% to 58.3%.

“Recent reviews of mammography screening have focused media attention on some of the risks of [the practice], such as callbacks for additional imaging and breast biopsies, downplaying the most important aspect of screening—that finding and treating breast cancer early saves women’s lives. Our study provides evidence of just how effective the combination of early detection and modern breast cancer treatment has been in averting breast cancer deaths,” said Dr. Hendrick.

He noted that currently, only about half of U.S. women over 40 years old receive regular screening mammography. “The best possible long-term effect of our findings would be to help women recognize that early detection and modern, personalized breast cancer treatment saves lives, and to encourage more women to get screened annually starting at age 40.”

Dr. Helvie added that additional benefits will likely be realized as research continues. “While we anticipate new scientific advances that will further reduce [deaths attributable to] breast cancer and morbidity, it is important that women continue to comply with existing screening and treatment recommendations,” he concluded.

Disclosure: The study authors' full disclosures can be found at onlinelibrary.wiley.com.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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